Urban Aerosols Induce Pro-inflammatory Cytokine Production in Macrophages and Cause Airway Inflammation in Vivo
| Autor: | Norio Itoh, Haruhiko Kamada, Hiromi Nabeshi, Kazuya Nagano, Takuya Yamashita, Hiroyuki Kayamuro, Yasuo Tsutsumi, Maho Fujimura, Ken-ichi Tanamoto, Yuichi Kawai, Masashi Muroi, Tadanori Mayumi, Yasuhiro Abe, Yuki Morishita, Tokuyuki Yoshida, Tomoaki Yoshikawa, Ryosuke Nakanishi, Kazuma Higashisaka, Shin-ichi Tsunoda, Yasuo Yoshioka, Kohei Yamashita |
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| Rok vydání: | 2010 |
| Předmět: |
Urban Population
medicine.medical_treatment Interleukin-1beta Pharmaceutical Science Inflammation complex mixtures Cell Line Mice Immune system Adjuvants Immunologic Administration Inhalation medicine Animals Macrophage Developing Countries Lung Aerosols Pharmacology Air Pollutants Mice Inbred BALB C medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry Macrophages Interleukin-8 NF-kappa B Interleukin Environmental Exposure General Medicine respiratory system medicine.disease Eosinophils Cytokine Bronchoalveolar lavage Immunology Cytokines Female Tumor necrosis factor alpha Bronchial Hyperreactivity medicine.symptom business Bronchoalveolar Lavage Fluid Infiltration (medical) Signal Transduction |
| Zdroj: | Biological and Pharmaceutical Bulletin. 33:780-783 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.33.780 |
| Popis: | Urban air pollution, especially in developing countries, is a crucial environmental problem. Urban aerosols may contain various kinds of substances and induce harmful effects such as allergic diseases. Therefore, it is critical to clarify the biological effects of urban aerosols on human health. In this study, we evaluated the induction of airway inflammation in vitro and in vivo due to exposure of urban aerosols. We investigated cytokine production and nuclear factor-kappaB (NF-kappaB) activation after stimulation of macrophage cells by exposure of urban aerosols. Urban aerosols were found to induce the production of interleukin (IL)-8, tumor necrosis factor-alpha and IL-1beta on macrophage cells. In addition, we showed that NF-kappaB pathway regulated the urban aerosols-induced inflammatory cytokine response. Moreover, the intranasal administration of urban aerosols resulted in increases in the total cell number in bronchoalveolar lavage and infiltration of eosinophils in lung tissue. These results indicate that urban aerosols induce respiratory inflammation and onset of inflammatory disease due to an activation of the immune system. |
| Databáze: | OpenAIRE |
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