Maternal high-fat diet is associated with impaired fetal lung development
| Autor: | Aaron P. Frank, Biff F. Palmer, Charles R. Rosenfeld, Katelyn E. Finch, Michael D. Neinast, Eugenia Morselli, Lisa Hahner, Deborah J. Clegg, Reina Sarah Mayor, Jordan A. Zehr, Rashmin C. Savani, Dinesh Rakheja, Jason Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
Blood Glucose Male medicine.medical_specialty Heart disease Physiology Placenta Intrauterine growth restriction Type 2 diabetes Placental insufficiency Chorioamnionitis Diet High-Fat Weight Gain Pregnancy Physiology (medical) Internal medicine medicine Animals Insulin Lung Asthma Inflammation Fetal Growth Retardation business.industry Cell Biology medicine.disease Mice Inbred C57BL Low birth weight Endocrinology Call for Papers Fetal lung Female medicine.symptom business |
| Popis: | Maternal nutrition has a profound long-term impact on infant health. Poor maternal nutrition influences placental development and fetal growth, resulting in low birth weight, which is strongly associated with the risk of developing chronic diseases, including heart disease, hypertension, asthma, and type 2 diabetes, later in life. Few studies have delineated the mechanisms by which maternal nutrition affects fetal lung development. Here, we report that maternal exposure to a diet high in fat (HFD) causes placental inflammation, resulting in placental insufficiency, fetal growth restriction (FGR), and inhibition of fetal lung development. Notably, pre- and postnatal exposure to maternal HFD also results in persistent alveolar simplification in the postnatal period. Our novel findings provide a strong association between maternal diet and fetal lung development. |
| Databáze: | OpenAIRE |
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