A cross-sectional study on factors associated with hypertension and genetic polymorphisms of renin-angiotensin-aldosterone system in Chinese hui pilgrims to hajj
Autor: | Xiao Ma, Jiaoyue Wang, Maolan Zeng, Yinxia Zhang, Aimin Yang, Haiping Yin, Zhanbiao Yu, Benzhong Zhang, Fangfang Shi |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male Aldosterone synthase China medicine.medical_specialty Cross-sectional study Population 030209 endocrinology & metabolism Renin-Angiotensin System 03 medical and health sciences RAAS 0302 clinical medicine Pilgrims Risk Factors Internal medicine Genotype Epidemiology Ethnicity Prevalence medicine Humans 030212 general & internal medicine Polymorphism Risk factor education Life Style education.field_of_study Polymorphism Genetic biology business.industry lcsh:Public aspects of medicine Public Health Environmental and Occupational Health lcsh:RA1-1270 Angiotensin-converting enzyme Odds ratio Middle Aged Cross-Sectional Studies Hypertension biology.protein Female business Research Article |
Zdroj: | BMC Public Health, Vol 19, Iss 1, Pp 1-11 (2019) BMC Public Health |
ISSN: | 1471-2458 |
Popis: | Background Hypertension is the leading risk factor for cardiovascular disease (CVD), however, the studies on lifestyle and genetic risks in Chinese pilgrims to Hajj was limited. The aim of this study is to examine the prevalence and associated lifestyle and genetic risks for hypertension among Hui Hajj pilgrims in China. Methods We performed a cross-sectional analysis of data in 1,465 participants aged 30–70 years who participated in a medical examination for Hui Hajj pilgrims from Gansu province, China in 2017. Multiple logistic regression was used to evaluate the association of potential risk factors with hypertension. Deoxyribonucleic acid (DNA) polymorphism was examined at sites in the renin-angiotensin-aldosterone system (RAAS). Results The prevalence of hypertension was 47% among this population. Lifestyle factors such as fried food preference (like vs. dislike: odds ratio [OR]: =1.53, 95% confidence interval [CI]: 1.13–2.09) and barbecued food preference (like vs. dislike: OR = 1.45, 95% CI: 1.06–1.97) were associated with elevated risk of hypertension among Hui pilgrims. Comparing with Angiotensin converting enzyme (ACE) rs4425 AA genotype, TT genotype was associated with hypertension risk (OR = 2.16, 95% CI: 1.17–4.00). Similar results were also observed for ACE rs4437 CC genotype (OR = 1.95, 95% CI: 1.07–3.55), Angiotensin II receptor (ATR) rs129876 AA genotype (OR = 4.10, 95% CI: 2.30–7.32) and Aldosterone synthase (CYP11B2) rs1912 TT genotype (OR = 2.82, 95% CI: 1.57–5.06) genotypes. Conclusions Unhealthy lifestyle and genetic factors were associated with the prevalence of hypertension in Chinese Hui pilgrims and their interactions were also observed. Electronic supplementary material The online version of this article (10.1186/s12889-019-7357-1) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
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