Calciprotein particles and fibroblast growth factor 23 contribute to the pathophysiology of hypercalcemia in a patient with renal sarcoidosis
| Autor: | Makoto Kuro-o, Daisuke Nagata, Toshiyuki Yamada, Yoshitaka Iwazu, Yutaka Miura, Shin-ichi Takeda |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Fibroblast growth factor 23
medicine.medical_specialty bisphosphonate 030232 urology & nephrology Exceptional Cases vitamin D urologic and male genital diseases Gastroenterology 03 medical and health sciences 0302 clinical medicine Prednisone Internal medicine nephrocalcinosis medicine Vitamin D and neurology AcademicSubjects/MED00340 Calcium metabolism Transplantation business.industry Acute kidney injury medicine.disease Pathophysiology Nephrology Sarcoidosis Nephrocalcinosis business phosphatemia medicine.drug nephrolithiasis |
| Zdroj: | Clinical Kidney Journal |
| ISSN: | 2048-8513 2048-8505 |
| Popis: | In patients with sarcoidosis, dysregulated calcium metabolism is one of the frequently observed complications. However, little attention has been paid to abnormal phosphate metabolism. Herein we present the case of a 42-year-old Japanese man with renal sarcoidosis who developed acute kidney injury due to hypercalcemia and nephrolithiasis. Laboratory data showed hypercalcemia with a normal serum phosphate level and high serum 1,25-hydroxyvitamin D3, fibroblast growth factor 23 (FGF23) and calciprotein particle (CPP) levels. After treatment with oral prednisone and bisphosphonate, the laboratory abnormalities and renal dysfunction were resolved. Thus increases in FGF23 and CPP may indicate disturbed phosphate metabolism in renal sarcoidosis. |
| Databáze: | OpenAIRE |
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