The Influence of Gene Interaction on Dosage Effects with Complete Anti-D Sera

Autor:	M. J. Celano, Stanley Lange, Marjory Stroup, Philip Levine
Rok vydání:	1959
Předmět:	business.industry Homozygous genotype Immune Sera Rho(D) Immune Globulin Hematology General Medicine Bioinformatics Molecular biology Chromosomes Transposition (music) Gene interaction Isoantibodies Immune serums Genotype Humans Medicine skin and connective tissue diseases business
Zdroj:	Vox Sanguinis. 4:33-39
ISSN:	1423-0410 0042-9007
DOI:	10.1159/000478443
Popis:	It has been known for a long time that DcE/DcE bloods give stronger reactions with anti-D sera than other common genotypes homozygous for D, e.g., DCe/DCe. It is suggested that the Ceppellini effect of inhibition of D by G in transposition can explain this observation. In bloods of genotype DCe/DCe, there may be a two-way inhibition of D and C in the transposition.The only common homozygous genotype in which C is not present is DcE/DcE. In the absence of C, anti-D sera are capable of exhibiting dosage effects.
Databáze:	OpenAIRE
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