Polyunsaturated fatty acids for the prevention of atrial fibrillation after cardiac surgery: An updated meta-analysis of randomized controlled trials
| Autor: | Guohui Zhang, Ya Zhen, Zhong-hua Bao, Aibin Tao, Baowei Zhang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Docosahexaenoic Acids Cochrane Library Placebo law.invention Diabetes Complications Postoperative Complications Randomized controlled trial law Internal medicine Preoperative Care medicine Humans Cardiac Surgical Procedures Randomized Controlled Trials as Topic business.industry Incidence Publication bias Cardiac surgery Atrial fibrillation Eicosapentaenoic acid Clinical trial Meta-analysis Eicosapentaenoic Acid Relative risk Fatty Acids Unsaturated Cardiology Polyunsaturated fatty acids lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiology. 63:53-59 |
| ISSN: | 0914-5087 |
| Popis: | Background Several clinical trials showed inconsistent results of the effect of polyunsaturated fatty acids (PUFA) on the incidence of post-operative atrial fibrillation (POAF). The aim of this meta-analysis is to investigate the effect of PUFA on the incidence of POAF in patients undergoing cardiac surgery. Methods and results PUBMED, EMBASE, Cochrane Library, and Google Scholar databases were searched for randomized controlled trials. Statistical heterogeneity was assessed using I2 statistic and Cochran's Q statistic. The effect of PUFA on the incidence of POAF was presented as risk ratio (RR) with 95% confidence intervals (CIs) using a fixed effect model or random effect model depending on statistical heterogeneity. Subgroup analyses were conducted based on the baseline characteristics of patients, types of surgery, the ratio of eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA), and the quality of the studies. Eight trials with 2687 patients were included in the analysis. Treatment with PUFA had no effect on the incidence of POAF in patients undergoing cardiac surgery compared to placebo [RR 0.86; 95% CI 0.71–1.04, p = 0.110]. Subgroup analyses showed the quality of the studies, the ratio of EPA/DHA, accompanied with diabetes might impact the effect of PUFA on POAF. No evidence of publication bias was detected. Conclusions The present analysis suggests that treatment with PUFA preoperatively has no effect on the incidence of POAF in patients undergoing open heart surgery. However, patients with diabetes might get benefits from the treatment with PUFA preoperatively. |
| Databáze: | OpenAIRE |
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