Anti-inflammatory activities of several 9 alpha-halo derivatives of adrenal steroids
| Autor: | Frank M. Singer, Aleck Borman |
|---|---|
| Rok vydání: | 1956 |
| Předmět: |
Inflammation
Stereochemistry medicine.drug_class Chemistry Adrenal cortex hormones medicine.medical_treatment Anti-Inflammatory Agents chemistry.chemical_element General Biochemistry Genetics and Molecular Biology Anti-inflammatory Steroid Hydroxylation chemistry.chemical_compound Active compound Adrenal Cortex Hormones medicine Fluorine Adrenal Cortex Molecule Steroids |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 92(1) |
| ISSN: | 0037-9727 |
| Popis: | SummaryThe anti-inflammatory properties of a number of 9 α-halo-11 β-hydroxy steroid derivatives have been compared with some of their halogen-free analogues. The substitution of a fluorine atom at the 9 α-position enhances activity. The presence of various hydroxyl groups in the steroid molecule is essential for maximum anti-inflammatory effect. Hydroxylation at the 17 α-position results in a steroid with increased anti-inflammatory activity. A considerably greater response is demonstrated by the introduction of a 21-hydroxyl group, while maximum activity is achieved by the presence of both 17 α- and 21-hydroxyl groups. The most active compound tested, containing a 9 α-fluorine atom and hydroxyl groups at carbon positions 11 β, 17 α, and 21. was fluoro F acetate. This steroid is approximately 13 times as potent an anti-inflammatory agent as E or F acetate. |
| Databáze: | OpenAIRE |
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