Exploration of Tumor-Suppressive MicroRNAs Silenced by DNA Hypermethylation in Oral Cancer
| Autor: | Ken Ichi Kozaki, Issei Imoto, Ken Omura, Seiki Mogi, Johji Inazawa |
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| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
E2F6 Transcription Factor Biology Transfection medicine.disease_cause Cell Line Tumor microRNA medicine Humans Gene silencing Gene Silencing Gene Expression Profiling Cancer Cyclin-Dependent Kinase 6 Methylation DNA Methylation medicine.disease Molecular biology MicroRNAs stomatognathic diseases mir-137 Cell Transformation Neoplastic Oncology CpG site DNA methylation Carcinoma Squamous Cell Mouth Neoplasms Carcinogenesis |
| Zdroj: | Cancer Research. 68:2094-2105 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.can-07-5194 |
| Popis: | In the last few years, microRNAs (miRNA) have started a revolution in molecular biology and emerged as key players in the carcinogenesis. They have been identified in various tumor types, showing that different sets of miRNAs are usually deregulated in different cancers. To identify the miRNA signature that was specific for oral squamous cell carcinoma (OSCC), we first examined expression profiles of 148 miRNAs in a panel of 18 OSCC cell lines and the immortalized oral keratinocyte line RT7 as a control. Compared with RT7, the expression of 54 miRNAs (36.5%) was frequently down-regulated in OSCC lines ( |
| Databáze: | OpenAIRE |
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