A nor-diterpene from Salvia sahendica leaves
| Autor: | Peyman Salehi, Markus Neuburger, Mahdi Moridi Farimani, Maria De Mieri, Sahar Mofidi Tabatabaei, Matthias Hamburger, Samad Nejad-Ebrahimi |
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| Rok vydání: | 2017 |
| Předmět: |
Staphylococcus aureus
Magnetic Resonance Spectroscopy Stereochemistry Breast Neoplasms Plant Science Crystallography X-Ray 01 natural sciences Biochemistry Analytical Chemistry chemistry.chemical_compound Column chromatography Cell Line Tumor Hexanes Humans Salvia Oleanolic Acid Oleanolic acid Molecular Structure biology Plant Extracts 010405 organic chemistry Chemistry Sclareol Organic Chemistry Absolute configuration Flavones biology.organism_classification Antineoplastic Agents Phytogenic Sitosterols Terpenoid Anti-Bacterial Agents 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry Phytochemical Female Lamiaceae Diterpenes Diterpene |
| Zdroj: | Natural Product Research. 31:1758-1765 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2017.1290619 |
| Popis: | Phytochemical investigation of n-hexane extract of Salvia sahendica by normal phase column chromatography resulted in the isolation of six compounds. Structures were established by 1D and 2D NMR spectroscopy, and HRMS, as a new norditerpene 1, and known terpenoids, sclareol (2), oleanolic acid (3), β-sitosterol (4), salvigenin (5) and 3α-hydroxy-11α,12α-epoxyoleanan-28,13β-olide (6). The absolute configuration of 1 was confirmed by a combination of X-ray single crystal analysis and electronic circular dichroism spectroscopy. In vitro cytotoxic activity on breast cancer cell line (MDA-MB-231) and also the antimicrobial activity of the pure compounds were tested against Staphylococcus aureus, Bacilus cereus and Escherichia coli. |
| Databáze: | OpenAIRE |
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