Radical–anion coupling through reagent design: hydroxylation of aryl halides†

Autor:	Andrew J. Greener, Ivan Ocaña, Victor Chechik, Will Owens-Ward, Michael J. James, Patrycja Ubysz, George Smith, Adrian C. Whitwood
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Aryl Radical Halide General Chemistry Oxime Combinatorial chemistry Ion Hydroxylation chemistry.chemical_compound Chemistry chemistry Reagent Phenols
Zdroj:	Chemical Science
ISSN:	2041-6539 2041-6520
Popis:	The design and development of an oxime-based hydroxylation reagent, which can chemoselectively convert aryl halides (X = F, Cl, Br, I) into phenols under operationally simple, transition-metal-free conditions is described. Key to the success of this approach was the identification of a reducing oxime anion which can interact and couple with open-shell aryl radicals. Experimental and computational studies support the proposed radical-nucleophilic substitution chain mechanism. The design and development of an oxime-based hydroxylation reagent, which can chemoselectively convert aryl halides (X = F, Cl, Br, I) into phenols under operationally simple, transition-metal-free conditions is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e46c05448ccb01c4748694d2a03407 http://europepmc.org/articles/PMC8580057 Zobrazit plný text záznamu