Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes
| Autor: | Yen Sung Lin, Yu Ting Shao, Ping Ching Wu, Chia Yuan Chang, Jui Chang Liu, Jiu Yao Wang, Wen Shuo Kuo, Edmund Cheung So |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
medicine.medical_treatment Nanochemistry Quantum yield Photodynamic therapy Water-soluble fullerenol 02 engineering and technology 010402 general chemistry Photochemistry medicine.disease_cause 01 natural sciences chemistry.chemical_compound lcsh:TA401-492 medicine General Materials Science Photosensitizer Singlet oxygen quantum yield Escherichia coli chemistry.chemical_classification Reactive oxygen species Two-photon excitation Nano Express Singlet oxygen 021001 nanoscience & nanotechnology Condensed Matter Physics Composition of exposed hydroxyl groups 0104 chemical sciences chemistry Excited state lcsh:Materials of engineering and construction. Mechanics of materials 0210 nano-technology |
| Zdroj: | Nanoscale Research Letters, Vol 15, Iss 1, Pp 1-15 (2020) Nanoscale Research Letters |
| ISSN: | 1556-276X |
| DOI: | 10.1186/s11671-020-03329-6 |
| Popis: | We successfully prepared water-soluble fullerenol [C60(OH)46] that exhibited a high singlet oxygen quantum yield and efficiently generated reactive oxygen species. Additionally, the water-soluble C60(OH)46 with a higher composition of exposed hydroxyl groups had superior two-photon stability and characteristics compared with that with a lower composition of such groups. Therefore, the prepared fullerenol can be an effective two-photon photosensitizer. The water-soluble C60(OH)46 had favorable two-photon properties. During two-photon photodynamic therapy, the water-soluble C60(OH)46 had substantial antimicrobial activity against Escherichia coli at an ultralow-energy level of 211.2 nJ pixel−1 with 800 scans and a photoexcited wavelength of 760 nm. |
| Databáze: | OpenAIRE |
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