Structure of the human interleukin-2 receptor gene
| Autor: | Warner C. Greene, Warren J. Leonard, Margery Sullivan, Joel M. Depper, Martin Krönke, Minoru Kanehisa, Nancy J. Peffer, Penny B. Svetlik |
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| Rok vydání: | 1985 |
| Předmět: |
Transcription
Genetic T-Lymphocytes Genes MHC Class II DNA Recombinant Biology Deltaretrovirus Exon Humans 5-HT5A receptor Amino Acid Sequence RNA Messenger Cloning Molecular Receptors Immunologic Peptide Chain Initiation Translational STAT4 Gene Protease-activated receptor 2 Repetitive Sequences Nucleic Acid Multidisciplinary Base Sequence GATA3 Receptors Interleukin-2 DNA Molecular biology Interleukin 10 RNA splicing Complement Factor B Retroviridae Infections |
| Zdroj: | Science (New York, N.Y.). 230(4726) |
| ISSN: | 0036-8075 |
| Popis: | The gene encoding the human interleukin-2 (IL-2) receptor consists of 8 exons spanning more than 25 kilobases on chromosome 10. Exons 2 and 4 were derived from a gene duplication event and unexpectedly also are homologous to the recognition domain of human complement factor B. Alternative messenger RNA (mRNA) splicing may delete exon 4 sequences, resulting in a mRNA that does not encode a functional IL-2 receptor. Leukemic T cells infected with HTLV-I and normal activated T cells express IL-2 receptors with identical deduced protein sequences. Receptor gene transcription is initiated at two principal sites in normal activated T cells. Adult T cell leukemia cells infected with HTLV-I show activity at both of these sites, but also at a third transcription initiation site. |
| Databáze: | OpenAIRE |
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