Results of a prospective dose-intensive regimen in 27 patients with small cell carcinoma of the ovary of the hypercalcemic type
| Autor: | B. Brun, I. Elghissassi, J.C. Barats, A. Lesoin, I. Sillet-Bach, Annie Rey, Catherine Lhommé, H. Crouet, Patricia Pautier, Vincent Ribrag, Pierre Duvillard, P. Morice, P. Kerbrat, F. Mayer |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Cyclophosphamide medicine.medical_treatment Small-cell carcinoma chemistry.chemical_compound Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Prospective Studies Carcinoma Small Cell Child Ovarian Neoplasms Chemotherapy Dose-Response Relationship Drug business.industry Hematology medicine.disease Debulking Chemotherapy regimen Carboplatin Surgery Regimen Treatment Outcome Oncology chemistry Hypercalcemia Female business medicine.drug |
| Zdroj: | Annals of Oncology. 18:1985-1989 |
| ISSN: | 0923-7534 |
| Popis: | Background The evaluation of first-line intensive combination therapy in small cell carcinoma of the ovary (SCCO). Patients and methods Debulking surgery; four to six cycles of chemotherapy with cisplatin (P) 80 mg/m2 day 1, adriamycin (A) 40 mg/m2 day 1, vepeside (V) 75 mg/m2/day days 1–3, cyclophosphamide (EP) 300 mg/m2/day days 1–3, every 3 weeks and granulocyte colony-stimulating factor with, in case of a complete remission, high-dose chemotherapy with carboplatin, vepeside, cyclophosphamide and stem-cell support. Results Twenty-seven patients (median age 25 years); International Federation of Gynecology and Obstetrics stage: five I, four IIC, 17 IIIC–IV and one unknown. Twenty patients underwent complete surgery. Eight patients progressed under chemotherapy. Among 18 patients in complete response (CR), 10 received high-dose chemotherapy (CT) (three stem-cell collection failures, two protocol violations, two disease progression and one refusal). The main grade 3–4 toxic effects were hematologic. There were eight relapses among the 18 CR, four of which were pelvic alone. Among the 27 patients, 13 died and 10 patients are in CR1, three in CR2. The median follow-up is 37 months (8–166) and the median duration of the 18 CR is 30 months (5–111). Overall survival at 1 and 3 years is 58% [confidence interval (CI) 40% to 75%] and 49% (CI 30% to 67%). Conclusions Initial dose-intensive therapy achieves interesting overall survival in SCCO. |
| Databáze: | OpenAIRE |
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