Relationship between microvessel count and postoperative survival in patients with intrahepatic cholangiocarcinoma
| Autor: | Toshiyuki Nakayama, Takeshi Nagayasu, Terumitsu Sawai, Tsutomu Tagawa, Kenichiro Shibata, Hiroaki Takeshita, Shigekazu Hidaka, Syuichi Tobinaga, Masato Araki, Atsushi Nanashima, Masaki Kunizaki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Oncology medicine.medical_specialty Hepatic resection medicine.medical_treatment CD34 Antigens CD34 hepatic resection Gastroenterology Cholangiocarcinoma Immunoenzyme Techniques Surgical oncology intrahepatic cholangiocarcinoma Internal medicine medicine microvessel count Humans Neoplasm Invasiveness In patient Postoperative Period Microvessel Intrahepatic Cholangiocarcinoma Neoplasm Staging Retrospective Studies business.industry Microcirculation Middle Aged Prognosis Postoperative survival Survival Rate body regions Bile Ducts Intrahepatic Treatment Outcome Bile Duct Neoplasms Lymphatic Metastasis Microvessels Female Surgery Neoplasm Recurrence Local Hepatectomy business human activities Follow-Up Studies |
| Zdroj: | Annals of surgical oncology. 16(8):2123-2129 |
| ISSN: | 1068-9265 |
| Popis: | BACKGROUND: The present study aimed to elucidate the relationship between microvessel count (MVC) according to CD34 expression and prognosis in intrahepatic cholangiocarcinoma (ICC) patients who underwent hepatectomy based on our preliminary study. METHODS: Relationships between MVC and clinicopathological factors were examined in 37 ICC patients. CD34 expression was analyzed using immunohistochemical methods. RESULTS: Median MVC for ICC patients was 140/mm(2), which was applied as a cutoff value. Lower MVC was significantly associated with larger tumor size, periductal infiltrating type, and advanced Japanese tumor-node-metastasis stage (p < 0.05). Univariate survival analysis identified higher carcinoembryonic antigen level, periductal infiltrating type, poor histological differentiation, and lower MVC as significantly associated with lower 5-year survival rates. The 5-year survival rate in the higher-MVC group was significantly greater than that in the lower-MVC group (44% vs. 7%, p = 0.048). According to Cox multivariate survival analysis, only periductal infiltrating type on macroscopic examination was identified as a significant independent risk factor for poor survival after hepatectomy (risk ratio 4.8; p = 0.006), not MVC (1.1; p = 0.82). CONCLUSION: Tumor MVC might offer a useful prognostic marker of ICC patient survival after hepatectomy and further investigation in a larger series is warranted. Annals of Surgical Oncology, 16(8), pp.2123-2129; 2009 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink