Craniofacial resection for malignant tumors involving the skull base in the elderly: an international collaborative study
| Autor: | Bhuvanesh Singh, Dan M. Fliss, Carl H. Snyderman, Jatin P. Shah, Dennis H. Kraus, Giulo Cantu, Snehal G. Patel, Ian Ganly, Luiz Paulo Kowalski |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Cancer Research Surgical margin medicine.medical_specialty Multivariate analysis medicine.medical_treatment Comorbidity Skull Base Neoplasms Postoperative Complications Medicine Humans Craniofacial Craniofacial surgery Aged Aged 80 and over Chemotherapy business.industry Skull Cancer Histology medicine.disease Primary tumor Combined Modality Therapy Surgery Treatment Outcome Oncology Face Carcinoma Squamous Cell Female business |
| Zdroj: | Cancer. 117(3) |
| ISSN: | 0008-543X |
| Popis: | BACKGROUND: In this study by the International Collaborative Group, the authors examined a large cohort of patients accumulated from multiple institutions that had experience in craniofacial surgery with the objective of reporting outcomes and complications for craniofacial resection (CFR) in the elderly. METHODS: One hundred seventy patients aged ≥70 years were included in the study. The median age was 75 years (range, 70-98 years). One hundred four patients (61%) had received previous single-modality or combined treatment, which included surgery in 79 patients (46%), radiation in 47 patients (28%), and chemotherapy in 13 patients (8%). The most common histology was squamous cell carcinoma (67 patients; 39%). The margins of resection were close or microscopically positive in 56 patients (33%). Sixty-eight patients received adjuvant radiotherapy (40%), and 3 patients received chemotherapy (2%). Complications were classified into overall, local, central nervous system (CNS), systemic, and orbital. Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) were determined by using the Kaplan-Meier method. Outcomes were compared with patients aged |
| Databáze: | OpenAIRE |
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