Calyhedins I-VI: Resin glycosides from the rhizomes of Calystegia hederacea
| Autor: | Nobuyoshi Yuhara, Souta Matsubara, Jian-Rong Zhou, Hitoshi Yoshimitsu, Junei Kinjo, Masafumi Okawa, Shin Yasuda, Ryota Tsuchihashi, Takaaki Shimohara, Toshihiro Nohara, Masateru Ono |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Calystegia biology Molecular Structure Stereochemistry Chemistry Glycoside Positive control Plant Science General Medicine Horticulture biology.organism_classification Biochemistry Rhizome Monosaccharide Glycosides Cytotoxicity Convolvulaceae Sugar Molecular Biology Resins Plant |
| Zdroj: | Phytochemistry. 190 |
| ISSN: | 1873-3700 |
| Popis: | Six previously undescribed resin glycosides, calyhedins I-VI, were isolated from the rhizomes of Calystegia hederacea Wall., which are the first genuine resin glycosides isolated from C. hederacea. The structures of calyhedins I-VI were determined based on spectroscopic data and chemical evidence. All the compounds have macrolactone structures (jalapins), and their sugar moieties were partially acylated by five organic acids. Calyhedins I, II-V, and VI have 27-, 28-, and 23-membered rings, respectively, and calyhedins IV-VI are the first jalapins with a sugar chain consisting of seven monosaccharides. Additionally, the cytotoxic activity of calyhedins II and III toward HL-60 human promyelocytic leukemia cells was evaluated. Both compounds demonstrated almost the same activity as the positive control, cisplatin. |
| Databáze: | OpenAIRE |
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