Pauci-immune Crescentic Glomerulonephritis Due to MGRS Crystalline Nephropathy
| Autor: | Benjamin Delprete, Samih H. Nasr, Faizan Babar, Shailendra Sharma, Amira Elshikh, Samar M. Said |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Amyloidosis 030232 urology & nephrology Glomerulonephritis 030204 cardiovascular system & hematology medicine.disease Nephropathy 03 medical and health sciences 0302 clinical medicine Nephrology Glomerulopathy Pauci-immune Monoclonal medicine medicine.symptom business Myeloma cast nephropathy Nephrology Round Kidney disease |
| Zdroj: | Kidney International Reports |
| ISSN: | 2468-0249 |
| DOI: | 10.1016/j.ekir.2019.07.013 |
| Popis: | There are several known mechanisms by which monoclonal Igs (MIg) or their subunits can cause kidney disease: (i) deposition in 1 or more kidney compartments, resulting in distinct clinicopathologic lesions, such as Ig-related amyloidosis, monoclonal Ig deposition disease, and a variety of glomerulonephritides, including cryoglobulinemic glomerulonephritis type I and II, immunotactoid glomerulonephritis, and proliferative glomerulonephritis with monoclonal immunoglobulin deposits; (ii) precipitation in tubular lumina (e.g., myeloma cast nephropathy); (iii) activation of the alternative pathway of complement (e.g., C3 glomerulopathy associated with monoclonal gammopathy, thrombotic microangiopathy associated with monoclonal gammopathy); (iv) cytokine activation (e.g., POEMS syndrome); and (v) crystallization in the renal vasculature (e.g., crystalglobulin-induced nephropathy).1, 2 Here, we describe an unusual case of monoclonal gammopathy of renal significance (MGRS)–associated crystalline nephropathy that does not conform to any of the previously described patterns of kidney involvement by monoclonal gammopathy. |
| Databáze: | OpenAIRE |
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