Thirty-eight-negative kinase 1 (TNK1) facilitates TNFα-induced apoptosis by blocking NF-κB activation
| Autor: | N Azoitei, Andreas Brey, Gail K. Adler, Simone Fulda, Tobias Busch, Thomas Seufferlein |
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| Rok vydání: | 2007 |
| Předmět: |
Fetal Proteins
Transcriptional Activation Cancer Research Programmed cell death Apoptosis Biology Transfection Transactivation Tumor Cells Cultured Genetics Humans ASK1 Molecular Biology MAP kinase kinase kinase Tumor Necrosis Factor-alpha Kinase NF-kappa B Transcription Factor RelA Protein-Tyrosine Kinases Caspases Cancer research Cyclin-dependent kinase 9 Signal transduction Tyrosine kinase HeLa Cells Signal Transduction |
| Zdroj: | Oncogene. 26:6536-6545 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/sj.onc.1210476 |
| Popis: | Thirty-eight-negative kinase 1 (TNK1) is a member of the ACK-family of nonreceptor tyrosine kinases and was originally cloned from CD34+/Lin-/CD38-hematopoietic stem/progenitor cells. The signaling pathways induced by TNK1 are largely unknown. Here, we report that expression and consequent activation of TNK1 enables tumor necrosis factor alpha (TNFalpha)-induced apoptosis by selectively inhibiting TNFalpha-induced activation of nuclear factor-kappaB (NF-kappaB). TNK1 has no effect on NF-kappaB DNA binding or the composition of the NF-kappaB complex; however, the kinase markedly prevents TNFalpha-induced NF-kappaB transactivation. TNK1 therefore acts as a novel molecular switch that can determine the properties of TNFalpha signaling and therefore cell death. |
| Databáze: | OpenAIRE |
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