Immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders

Autor: María Laura Palumbo, Ana María Genaro, Alejandro David Moroni, María Micaela Castro, Adriana Laura Burgueño, Sofía Quiroga
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Autoimmunity
medicine.disease_cause
Autoantigens
Medicine
NEURODEGENERACION
Invited Reviews
General Pharmacology
Toxicology and Pharmaceutics
NEUROPROTECCION
Research Highlights from South America
Therapeutic strategy
neurodegeneration
Neurodegenerative Diseases
Parkinson Disease
SISTEMA INMUNOLOGICO
Neuroprotection
Stroke
medicine.anatomical_structure
Neurology
protective autoimmunity
medicine.symptom
Central nervous system
Inflammation
RM1-950
Immunomodulation
Immune system
Alzheimer Disease
Protective autoimmunity
Animals
Humans
Immunologic Factors
Proteostasis Deficiencies
Spinal Cord Injuries
Invited Review
CNS‐related peptides
business.industry
Regeneration (biology)
Amyotrophic Lateral Sclerosis
SISTEMA NERVIOSO CENTRAL
Immunization
Passive
Myelin Basic Protein
ENFERMEDADES NEURODEGENERATIVAS
Glatiramer Acetate
Peptide Fragments
Nerve Regeneration
Therapeutics. Pharmacology
Peptides
business
Neuroscience
Zdroj: Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
Pharmacol Res Perspect. 2021, 9 (5)
Pharmacology Research & Perspectives
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
ISSN: 2052-1707
Popis: Neurodegenerative diseases (NDD) are disorders characterized by the progressive loss of neurons affecting motor, sensory, and/or cognitive functions. The incidence of these diseases is increasing and has a great impact due to their high morbidity and mortality. Unfortunately, current therapeutic strategies only temporarily improve the patients’ quality of life but are insufficient for completely alleviating the symptoms. An interaction between the immune system and the central nervous system (CNS) is widely associated with neuronal damage in NDD. Usually, immune cell infiltration has been identified with inflammation and is considered harmful to the injured CNS. However, the immune system has a crucial role in the protection and regeneration of the injured CNS. Nowadays, there is a consensus that deregulation of immune homeostasis may represent one of the key initial steps in NDD. Dr. Michal Schwartz originally conceived the concept of “protective autoimmunity” (PA) as a well‐controlled peripheral inflammatory reaction after injury, essential for neuroprotection and regeneration. Several studies suggested that immunizing with a weaker version of the neural self‐antigen would generate PA without degenerative autoimmunity. The development of CNS‐related peptides with immunomodulatory neuroprotective effect led to important research to evaluate their use in chronic and acute NDD. In this review, we refer to the role of PA and the potential applications of active immunization as a therapeutic option for NDD treatment. In particular, we focus on the experimental and clinical promissory findings for CNS‐related peptides with beneficial immunomodulatory effects.
Considerable evidence indicated that the loss of immune homeostasis may represent one of the key initial steps in neurodegenerative disease (NDD). Several studies suggested that immunizing with a weaker version of the neural self‐antigen induces mechanisms that bring to protection and regeneration of the injured central nervous system (CNS). The development of CNS‐related peptides with immunomodulatory neuroprotective effects led to important research to evaluate their use in chronic and acute NDD. In this review, we refer to the potential applications of active immunization as a therapeutic strategy for NDD treatment. In particular, we focus on the experimental and clinical findings for CNS‐related peptides with beneficial immunomodulatory effects.
Databáze: OpenAIRE
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