Pre-eclampsia but not pregnancy-induced hypertension is a risk factor for diabetic nephropathy in type 1 diabetic women
| Autor: | J. Fagerudd, Mats Rönnback, Daniel Gordin, Per-Henrik Groop, Risto Kaaja, Carol Forsblom, Vilho Hiilesmaa, Kari Teramo |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy Trimester Third Endocrinology Diabetes and Metabolism Pregnancy Complications Cardiovascular Body Mass Index Preeclampsia Diabetic nephropathy Pre-Eclampsia Pregnancy Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Birth Weight Humans Diabetic Nephropathies Risk factor reproductive and urinary physiology Glycated Hemoglobin Type 1 diabetes Eclampsia business.industry Infant Newborn medicine.disease female genital diseases and pregnancy complications Pregnancy Complications Diabetes Mellitus Type 1 Endocrinology Female business Kidney disease |
| Zdroj: | Diabetologia. 50:516-522 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/s00125-006-0544-5 |
| Popis: | Our aim was to study whether pre-eclampsia and pregnancy-induced hypertension are predictors of diabetic nephropathy in type 1 diabetic women.A total of 203 type 1 diabetic women, who were pregnant between 1988 and 1996 and followed at the Department of Obstetrics and Gynaecology in Helsinki, were re-assessed after an average of 11 years within the nationwide, multi-centre Finnish Diabetic Nephropathy Study. Diabetic nephropathy was defined as microalbuminuria, macroalbuminuria or end-stage renal disease.Patients with prior pre-eclampsia had diabetic nephropathy more often than patients with a normotensive pregnancy (diabetic nephropathy vs normal albumin excretion rate: 41.9% vs 8.9%; p0.001), whereas patients with a history of pregnancy-induced hypertension did not (10.3% vs 8.9%; p=0.81). CHD was more prevalent in patients with a history of pre-eclampsia than in patients with a normotensive pregnancy (12.2% vs. 2.2%; p=0.03). Pre-eclampsia (odds ratio [OR] 7.7, 95% CI 1.6-36.1; p=0.01) and HbA(1c) (OR 2.0, 95% CI 1.1-3.8; p0.05) were associated with incident diabetic nephropathy even when adjusted for follow-up time, BMI, smoking, diabetes duration and age.These data suggest that a history of pre-eclamptic pregnancy but not pregnancy-induced hypertension is associated with an elevated risk of diabetic nephropathy. |
| Databáze: | OpenAIRE |
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