Intra-articular glucocorticoid injections decrease the number of steroid hormone receptor positive cells in synovial tissue of patients with persistent knee arthritis
| Autor: | Z. N. Jahangier, Johannes W. J. Bijlsma, Silvia Capellino, Floris P J G Lafeber, Marlies C van der Goes, Rainer H. Straub, Johannes W G Jacobs, M. J. G. Wenting, Luise Rauch |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Knee arthritis Receptors Steroid medicine.medical_specialty Knee Joint Steroid hormone receptor medicine.drug_class T-Lymphocytes Immunology 610 Medizin Arthritis Osteoarthritis Triamcinolone General Biochemistry Genetics and Molecular Biology Injections Intra-Articular Rheumatology Internal medicine medicine Humans Immunology and Allergy Receptor Glucocorticoids Pain Measurement ddc:610 medicine.diagnostic_test business.industry Macrophages Synovial Membrane Fibroblasts Middle Aged Osteoarthritis Knee medicine.disease Androgen Immunohistochemistry Endocrinology Erythrocyte sedimentation rate Female business Glucocorticoid medicine.drug |
| DOI: | 10.5283/epub.36150 |
| Popis: | Objectives: To explore changes in the number of steroid hormone receptor positive cells in synovial tissue (ST) after intra-articular glucocorticoid injection, to correlate these changes with changes in clinical variables, and to evaluate whether the number of steroid hormone receptor positive cells predicted the clinical response to glucocorticoid injection. Methods: Fourteen patients with persistent knee arthritis despite at least two previous injections in an outpatient setting received an intra-articular injection with glucocorticoids, followed by 3 days of admission with bed rest. Clinical efficacy was assessed at 6 and 12 weeks. ST biopsies were performed 2 weeks before and 12 weeks after the injection. The presence of different cell types (T cells, macrophages, fibroblast-like synoviocytes) and numbers of glucocorticoid, androgen and oestrogen α and β receptor positive cells were evaluated by histochemistry. Results: Patients showed, despite previous failures, good clinical response to glucocorticoid injection, with significant improvement in erythrocyte sedimentation rate, visual analogue scale (VAS) for pain, and joint disability score. The number of steroid hormone receptor positive cells decreased markedly (p |
| Databáze: | OpenAIRE |
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