Natural killer cell degranulation capacity predicts early onset of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with tuberculosis
| Autor: | Polidy, Pean, Eric, Nerrienet, Yoann, Madec, Laurence, Borand, Didier, Laureillard, Marcelo, Fernandez, Olivier, Marcy, Chan, Sarin, Kerya, Phon, Sylvia, Taylor, Gianfranco, Pancino, Françoise, Barré-Sinoussi, Daniel, Scott-Algara, Sirenda, Vong |
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| Přispěvatelé: | Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Unité d'Épidémiologie et de Santé Publique [Phnom Penh], Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Cambodian Health Committee, Agence Nationale de Recherche sur le Sida [Vietnam], ANRS France Recherche Nord & sud Sida-hiv hépatites, Harvard Medical School AIDS Initiative in Vietnam (HAIVN), Harvard Medical School [Boston] (HMS), Calmette Hospital [Phnom Penh], Régulation des Infections Rétrovirales, Institut Pasteur [Paris], This work was supported by the Agence Nationale de Recherche sur le Sida (ANRS, the French National Agency for AIDS and Hepatitis Research) project number 12153., The authors thank all of the patients who participated in this study and the medical staff of Khmer Soviet Friendship Hospital in Phnom Penh, Dongkeo Referral Hospital in Takeo, Preah Kossamak Hospital in Phnom Penh, and Svay Rieng Referral Hospital., Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Institut Pasteur [Paris] (IP) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Male MESH: Killer Cells Natural/immunology urologic and male genital diseases Biochemistry Cell Degranulation MESH: Antiretroviral Therapy Highly Active 0302 clinical medicine [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Antiretroviral Therapy Highly Active Medicine MESH: Interferon-gamma/metabolism 0303 health sciences natural killer cells Coinfection Hazard ratio MESH: HIV Infections/drug therapy MESH: Immune Reconstitution Inflammatory Syndrome/complications [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology Hematology Acquired immune system female genital diseases and pregnancy complications 3. Good health Killer Cells Natural medicine.anatomical_structure tuberculosis Receptors Natural Killer Cell [SDV.IMM]Life Sciences [q-bio]/Immunology Female MESH: Coinfection/immunology MESH: Tuberculosis/immunology Viral load MESH: Lectins C-Type/metabolism Adult Tuberculosis MESH: Cell Degranulation/immunology Immunology MESH: HIV Infections/complications hiv infections 03 medical and health sciences Interferon-gamma Immune reconstitution inflammatory syndrome Antigens CD Humans Lectins C-Type cardiovascular diseases Iris (anatomy) MESH: Antigens Differentiation T-Lymphocyte/metabolism Natural killer cell degranulation MESH: Immune Reconstitution Inflammatory Syndrome/immunology 030304 developmental biology MESH: Humans MESH: Killer Cells Natural/metabolism business.industry urogenital system MESH: Antigens CD/metabolism fungi MESH: Adult Cell Biology medicine.disease immune reconstitution inflammatory syndrome MESH: Male MESH: HIV Infections/immunology MESH: Tuberculosis/complications MESH: Receptors Natural Killer Cell/metabolism business MESH: Female 030215 immunology |
| Zdroj: | Blood Blood, American Society of Hematology, 2012, 119 (14), pp.3315-3320. ⟨10.1182/blood-2011-09-377523⟩ Blood, 2012, 119 (14), pp.3315-3320. ⟨10.1182/blood-2011-09-377523⟩ |
| ISSN: | 0006-4971 1528-0020 |
| DOI: | 10.1182/blood-2011-09-377523⟩ |
| Popis: | Immune reconstitution inflammatory syndrome (IRIS) is a common and potentially serious complication occurring in HIV-infected patients being treated for tuberculosis (TB) using combined antiretroviral treatment. A role of adaptive immunity has been suggested in the onset of IRIS, whereas the role of natural killer (NK) cells has not yet been explored. The present study sought to examine the involvement of NK cells in the onset of IRIS in HIV-infected patients with TB and to identify predictive markers of IRIS. A total of 128 HIV-infected patients with TB from the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) trial were enrolled in Cambodia. Thirty-seven of the 128 patients developed IRIS. At inclusion, patients had low CD4 cell counts (27 cells/mm3) and high plasma viral load (5.76 and 5.50 log/mL in IRIS and non-IRIS patients, respectively). At baseline, NK-cell degranulation capacity was significantly higher in IRIS patients than in non-IRIS patients (9.6% vs 6.38%, P < .005). At IRIS onset, degranulation capacity did not differ between patients, whereas activating receptor expression was lower in IRIS patients. Patients with degranulation levels > 10.84% had a higher risk of IRIS (P = .002 by log-rank test). Degranulation level at baseline was the most important IRIS predictor (hazard ratio = 4.41; 95% confidence interval, 1.60-12.16). We conclude that NK-degranulation levels identify higher IRIS risk in HIV-infected patients with TB. |
| Databáze: | OpenAIRE |
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