The effect of a growth hormone receptor antagonist drug on proliferative diabetic retinopathy
Autor: | K. J. Ellis, Roy W. Beck, R. N. Frank, R. T. Kraker |
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Rok vydání: | 2001 |
Předmět: |
Male
Drug medicine.medical_specialty media_common.quotation_subject Internal medicine medicine Humans Prospective Studies Insulin-Like Growth Factor I Growth Hormone Receptor Antagonist media_common Diabetic Retinopathy Human Growth Hormone business.industry Receptors Somatotropin Diabetic retinopathy Middle Aged medicine.disease Ophthalmology Diabetes Mellitus Type 1 Treatment Outcome Endocrinology Diabetes Mellitus Type 2 Drug Evaluation Female business |
Zdroj: | Ophthalmology. 108:2266-2272 |
ISSN: | 0161-6420 |
DOI: | 10.1016/s0161-6420(01)00853-3 |
Popis: | This study investigated whether the growth hormone receptor antagonist pegvisomant could produce regression of diabetic retinal neovascularization.A prospective, single-group, open-label, phase IIa multicenter trial was conducted.Twenty-five patients with diabetes mellitus (13 with type 1 and 12 with type 2) and proliferative diabetic retinopathy aged 21 years or older were enrolled.Patients received an initial loading dose of 100 mg pegvisomant by subcutaneous injection, followed by self-administered injections of 20 mg daily for 12 weeks. The treatment period was followed by a 12-week period during which patients were observed off treatment.The effect of treatment on diabetic retinopathy was evaluated from fundus photographs that were graded at a central reading center.Regression of retinopathy was not observed in any patient. At the end of the treatment period, the extent of neovascularization in the study eye was unchanged in 16 patients (9 of 13 with type 1 and 7 of 12 with type 2) and had progressed in 9 patients (4 of 13 with type 1 and 5 of 12 with type 2). The maximum reduction from baseline per patient in the insulin-like growth factor-I (IGF-I) serum level averaged 55%; 17 (68%) of the 25 patients had a greater than 50% reduction in IGF-I. After treatment was discontinued, IGF-I levels returned to baseline.This study did not find evidence that pegvisomant could produce regression of diabetic retinal neovascularization. |
Databáze: | OpenAIRE |
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