Extracorporeal Circulation Interference on Emergence from Anesthesia in Patients Submitted to Myocardial Revascularization
| Autor: | Luiz Marcelo Sá Malbouisson, Luciana Moraes dos Santos, Maria José Carvalho Carmona, Marilde de Albuquerque Piccioni, Ricardo Antonio Guimarães Barbosa |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Extracorporeal Circulation Myocardial revascularization genetic structures Sedation EQUIPAMENTOS Oxigenador circulação extracorpórea SEDACIÓN Profunda Consciousness Monitors EQUIPOS Oxigenador circulación extracorpórea Pharmacokinetics medicine Myocardial Revascularization Humans In patient Propofol Aged FARMACOLOGÍA Farmacocinética Ramsay sedation scale ANESTÉSICOS Venoso propofol business.industry Extracorporeal circulation SEDAÇÃO Profunda Middle Aged eye diseases stomatognathic diseases Anesthesiology and Pain Medicine Anesthesia Bispectral index Anesthesia Recovery Period Female sense organs medicine.symptom Deep Sedation business FARMACOLOGIA Farmacocinética medicine.drug |
| Zdroj: | ResearcherID |
| ISSN: | 0034-7094 |
| DOI: | 10.1016/s0034-7094(12)70130-7 |
| Popis: | Summary Background and objectives Extracorporeal circulation (ECC) may change drug pharmacokinetics as well as brain function. The objectives of this study are to compare emergence time and postoperative sedation intensity assessed by the bispectral index (BIS) and the Ramsay sedation scale in patients undergoing myocardial revascularization (MR) with or without ECC. Method Ten patients undergoing MR with ECC (ECC group) and 10 with no ECC (no-ECC group) were administered with sufentanyl, propofol 2.0 μg.mL−1 and pancuronium target controlled infusion. After surgery, propofol infusion was reduced to 1 μg.mL−1 and suspended when extubation was indicated. Patients BIS, Ramsay scale and time to wake up were assessed. Results The ECC group showed lower BIS values beginning at 60 minutes after surgery (no-ECC = 66 ± 13 and ECC = 53 ± 14, p = 0.01) until 120 minutes after infusion (no-ECC = 85 ± 8 and ECC = 73 ± 12, p = 0.02). Sedation level measured by the Ramsay scale was higher in the ECC group at 30 minutes after the end of the surgery (no-ECC = 5 ± 1 and ECC = 6 ± 0, p = 0.021), at the end of infusion (no-ECC = 5 ± 1 and ECC = 6 ± 1, p = 0.012) and 5 minutes after the end of infusion (no-ECC = 4 ± 1 and ECC = 5 ± 0.42, p = 0.039). Emergence from anesthesia time was higher in the ECC group (no-ECC = 217 ± 81 and ECC = 319 ± 118, p = 0.038). Conclusions There was a higher intensity of sedation after the end of surgery and a longer wake up time in ECC group, suggesting changes in the pharmacokinetics of propofol or effects of ECC on central nervous system. |
| Databáze: | OpenAIRE |
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