Therapeutic decision-making for patients with fluctuating mitral regurgitation
| Autor: | Giovanni La Canna, Khalil Fattouch, Patrizio Lancellotti |
|---|---|
| Přispěvatelé: | Lancellotti, P., Fattouch, K., La Canna, G. |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Mitral Valve Annuloplasty medicine.medical_treatment Clinical Decision-Making Cardiac resynchronization therapy Doppler echocardiography Revascularization Cardiac Resynchronization Therapy Echocardiography Stre Mitral valve annuloplasty Internal medicine medicine.artery Mitral valve Stress Echocardiography Humans Medicine Echocardiography Doppler Echocardiography Stress Exercise Mitral Valve Mitral Valve Insufficiency Cardiology and Cardiovascular Medicine Medicine (all) Mitral regurgitation medicine.diagnostic_test business.industry medicine.anatomical_structure Pulmonary artery Cardiology Radiology business Human |
| Zdroj: | Nature Reviews Cardiology. 12:212-219 |
| ISSN: | 1759-5010 1759-5002 |
| DOI: | 10.1038/nrcardio.2015.16 |
| Popis: | Mitral regurgitation (MR) is a common, progressive, and difficult-to-manage disease. MR is dynamic in nature, with physiological fluctuations occurring in response to various stimuli such as exercise and ischaemia, which can precipitate the development of symptoms and subsequent cardiac events. In both chronic primary and secondary MR, the dynamic behaviour of MR can be reliably examined during stress echocardiography. Dynamic fluctuation of MR can also have prognostic value; patients with a marked increase in regurgitant volume or who exhibit increased systolic pulmonary artery pressure during exercise have lower symptom-free survival than those who do not experience significant changes in MR and systolic pulmonary artery pressure during exercise. Identifying patients who have dynamic MR, and understanding the mechanisms underlying the condition, can potentially influence revascularization strategies (such as the surgical restoration of coronary blood flow) and interventional treatment (including cardiac resynchronization therapy and new approaches targeted to the mitral valve). |
| Databáze: | OpenAIRE |
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