In vivo assessment of the host reactions to the biodegradation of the two novel magnesium alloys ZEK100 and AX30 in an animal model
| Autor: | Dina Dziuba, Dirk Bormann, Janin Reifenrath, Jan-Marten Seitz, Brigitte von Rechenberg, Andrea Meyer-Lindenberg, Tim Andreas Huehnerschulte, Henning Windhagen |
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| Přispěvatelé: | University of Zurich, Reifenrath, Janin |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
X-ray microtomography
rabbit model Degradation Bone Marrow Materials Testing Magnesium Tolonium Chloride Minerals Radiological and Ultrasound Technology 630 Agriculture orthopedic implants bone-resorption General Medicine Prostheses and Implants Resorption medicine.anatomical_structure lcsh:R855-855.5 Models Animal emerging insights Biocompatibility Rabbits extracellular calcium Histology lcsh:Medical technology mechanical-properties Biomedical Engineering chemistry.chemical_element mu?-computed tomography resorbable implants 2204 Biomedical Engineering Bone resorption Biomaterials In vivo medicine Alloys Animals 2741 Radiology Nuclear Medicine and Imaging Radiology Nuclear Medicine and imaging ddc:610 vitro corrosion 3614 Radiological and Ultrasound Technology Staining and Labeling Research 2502 Biomaterials μ-computed tomography X-Ray Microtomography corrosion behavior Apposition chemistry 570 Life sciences biology Bone marrow 10090 Equine Department Dewey Decimal Classification::600 | Technik::610 | Medizin Gesundheit months implantation duration Biomedical engineering |
| Zdroj: | BioMedical Engineering OnLine, Vol 11, Iss 1, p 14 (2012) BioMedical Engineering Biomedical Engineering Online 11 (2012) |
| Popis: | Background Most studies on biodegradable magnesium implants published recently use magnesium-calcium-alloys or magnesium-aluminum-rare earth-alloys. However, since rare earths are a mixture of elements and their toxicity is unclear, a reduced content of rare earths is favorable. The present study assesses the in vivo biocompatibility of two new magnesium alloys which have a reduced content (ZEK100) or contain no rare earths at all (AX30). Methods 24 rabbits were randomized into 4 groups (AX30 or ZEK100, 3 or 6 months, respectively) and cylindrical pins were inserted in their tibiae. To assess the biodegradation μCT scans and histological examinations were performed. Results The μCT scans showed that until month three ZEK100 degrades faster than AX30, but this difference is leveled out after 6 months. Histology revealed that both materials induce adverse host reactions and high numbers of osteoclasts in the recipient bone. The mineral apposition rates of both materials groups were high. Conclusions Both alloys display favorable degradation characteristics, but they induce adverse host reactions, namely an osteoclast-driven resorption of bone and a subsequent periosteal formation of new bone. Therefore, the biocompatibility of ZEK100 and AX30 is questionable and further studies, which should focus on the interactions on cellular level, are needed. |
| Databáze: | OpenAIRE |
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