Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury
| Autor: | Xiaoxiang Liu, Koji Naito, Motonori Hashimoto, Atsushi Yamaguchi, Hajime Horii, Toshihide Yamashita |
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| Rok vydání: | 2009 |
| Předmět: |
RHOA
Neurite Central nervous system Biophysics Nerve Tissue Proteins Inhibitory postsynaptic potential Biochemistry Myelin Neurites medicine Animals Rats Wistar Axon Molecular Biology Spinal Cord Injuries Cerebral Cortex Neurons biology Chemistry Membrane Proteins Repulsive guidance molecule Cell Biology Anatomy Entorhinal cortex Nerve Regeneration Rats Cell biology medicine.anatomical_structure nervous system biology.protein |
| Zdroj: | Biochemical and Biophysical Research Communications. 382:795-800 |
| ISSN: | 0006-291X |
| Popis: | Neuronal axons are guided by attractive and repulsive cues in their local environment. Since the identification of the repulsive guidance molecule (RGM) a (RGMa) as an axon repellent in the visual system, diverse functions, as part of the developing and adult central nervous system (CNS), have been ascribed to it. The binding of RGMa to its receptor neogenin has been shown to induce RhoA activation, leading to inhibitory/repulsive behavior and the collapse of the neuronal growth cone. In this paper, we provide evidence to suggest the involvement of RGMb, another member of the RGM family, in the rat CNS. RGMb inhibits neurite outgrowth in postnatal cerebellar granule neurons (CGNs) in vitro. RGMb is expressed by oligodendrocytes and neurons in the adult rat CNS, and the expression of this molecule is upregulated around the site of spinal cord injury. RGMb is present in myelin isolated from an adult rat brain. RGMb and neogenin are coexpressed in CGNs and entorhinal cortex neurons. These findings suggest that RGMb is a myelin-derived inhibitor of axon growth in the CNS. Inhibition of RGMb may provide an alternative approach for the treatment of spinal injuries. |
| Databáze: | OpenAIRE |
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