A Short-Term Resistance Training Circuit Improved Antioxidants in Sedentary Adults with Down Syndrome

Autor: Antonio Diaz, Ignacio Rosety, José Ramón Alvero-Cruz, S. Elosegui, M.A. Rosety, Ángel Oliva-Pascual-Vaca, Francisco Javier Ordonez, Marco Bernardi, Manuel Rosety-Rodriguez, Francisco Brenes
Přispěvatelé: Anatomía y Embriología Humana, Didáctica de la Educación Física, Plástica y Musical, Medicina
Rok vydání: 2021
Předmět:
Male
Aging
Time Factors
Antioxidant
medicine.medical_treatment
Glutathione reductase
carbonyl groups
Biochemistry
Antioxidants
Protein Carbonylation
chemistry.chemical_compound
0302 clinical medicine
Malondialdehyde
Medicine
030212 general & internal medicine
Plasma malondialdehyde
education.field_of_study
Hand Strength
General Medicine
Catalase
Glutathione
Female
Oxidation-Reduction
Research Article
Adult
total antioxidant status
medicine.medical_specialty
Down syndrome
Article Subject
Population
Thiobarbituric Acid Reactive Substances
Exercise training
Young Adult
03 medical and health sciences
Internal medicine
Humans
Aerobic exercise
education
QH573-671
Superoxide Dismutase
business.industry
Resistance training
Resistance Training
Exercise training
total antioxidant status
Plasma malondialdehyde
carbonyl groups
Cell Biology
medicine.disease
Oxidative Stress
Endocrinology
chemistry
Spain
Down Syndrome
Sedentary Behavior
Cytology
business
030217 neurology & neurosurgery
Zdroj: Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 8811153
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
instname
RODIN: Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
Universidad de Cádiz
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
ISSN: 1942-0994
1942-0900
Popis: Previous studies have found aerobic training improved oxidative damage in people with Down syndrome (DS). However, there is a lack of information regarding the influence of resistance training on redox imbalance in this population. Accordingly, this study was conducted to determine the effect of resistance training (RT) on antioxidant defence system in sedentary adults with DS. Thirty-six male adults with DS were recruited through different community support groups. Eighteen were randomly assigned to perform a circuit RT program with 6 stations, 3 days/week for 12 weeks. Plasma total antioxidant status (TAS), reduced glutathione (GHS), ascorbate, serum α-tocopherol, and erythrocyte glutathione reductase activity were assessed. Plasma malondialdehyde (MDA) and carbonyl groups (CG) were assessed as markers of oxidative damage. Muscle strength was also measured. Dynamic torque of knee extensors and flexors as well as maximal handgrip strength was significantly improved after the completion of the training program. Plasma levels of TAS and erythrocyte glutathione reductase (GR) activity were significantly increased. Conversely, MDA and CG levels were significantly reduced. It was concluded RT improved antioxidant defence system and reduced oxidative damage in adults with DS. Further, long-term studies are required to determine whether the increased antioxidant system may improve clinical outcomes of adults with DS.
Databáze: OpenAIRE
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