A Short-Term Resistance Training Circuit Improved Antioxidants in Sedentary Adults with Down Syndrome
Autor: | Antonio Diaz, Ignacio Rosety, José Ramón Alvero-Cruz, S. Elosegui, M.A. Rosety, Ángel Oliva-Pascual-Vaca, Francisco Javier Ordonez, Marco Bernardi, Manuel Rosety-Rodriguez, Francisco Brenes |
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Přispěvatelé: | Anatomía y Embriología Humana, Didáctica de la Educación Física, Plástica y Musical, Medicina |
Rok vydání: | 2021 |
Předmět: |
Male
Aging Time Factors Antioxidant medicine.medical_treatment Glutathione reductase carbonyl groups Biochemistry Antioxidants Protein Carbonylation chemistry.chemical_compound 0302 clinical medicine Malondialdehyde Medicine 030212 general & internal medicine Plasma malondialdehyde education.field_of_study Hand Strength General Medicine Catalase Glutathione Female Oxidation-Reduction Research Article Adult total antioxidant status medicine.medical_specialty Down syndrome Article Subject Population Thiobarbituric Acid Reactive Substances Exercise training Young Adult 03 medical and health sciences Internal medicine Humans Aerobic exercise education QH573-671 Superoxide Dismutase business.industry Resistance training Resistance Training Exercise training total antioxidant status Plasma malondialdehyde carbonyl groups Cell Biology medicine.disease Oxidative Stress Endocrinology chemistry Spain Down Syndrome Sedentary Behavior Cytology business 030217 neurology & neurosurgery |
Zdroj: | Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 8811153 RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz instname RODIN: Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz Universidad de Cádiz Oxidative Medicine and Cellular Longevity, Vol 2021 (2021) Oxidative Medicine and Cellular Longevity |
ISSN: | 1942-0994 1942-0900 |
Popis: | Previous studies have found aerobic training improved oxidative damage in people with Down syndrome (DS). However, there is a lack of information regarding the influence of resistance training on redox imbalance in this population. Accordingly, this study was conducted to determine the effect of resistance training (RT) on antioxidant defence system in sedentary adults with DS. Thirty-six male adults with DS were recruited through different community support groups. Eighteen were randomly assigned to perform a circuit RT program with 6 stations, 3 days/week for 12 weeks. Plasma total antioxidant status (TAS), reduced glutathione (GHS), ascorbate, serum α-tocopherol, and erythrocyte glutathione reductase activity were assessed. Plasma malondialdehyde (MDA) and carbonyl groups (CG) were assessed as markers of oxidative damage. Muscle strength was also measured. Dynamic torque of knee extensors and flexors as well as maximal handgrip strength was significantly improved after the completion of the training program. Plasma levels of TAS and erythrocyte glutathione reductase (GR) activity were significantly increased. Conversely, MDA and CG levels were significantly reduced. It was concluded RT improved antioxidant defence system and reduced oxidative damage in adults with DS. Further, long-term studies are required to determine whether the increased antioxidant system may improve clinical outcomes of adults with DS. |
Databáze: | OpenAIRE |
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