Detection of varicella zoster virus DNA and viral antigen in the late stage of bilateral acute retinal necrosis syndrome
| Autor: | Gottfried O. H. Naumann, Hartmut Wenkel, Volker Rummelt, Gerhard Jahn, C. Rummelt, Hans J. Meyer |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pathology
medicine.medical_specialty Herpesvirus 3 Human Fundus Oculi viruses Eye disease Retinitis medicine.disease_cause Virus Herpesviridae chemistry.chemical_compound medicine Humans Optic neuritis Antigens Viral business.industry Varicella zoster virus Nucleic Acid Hybridization Retinal Retinal Necrosis Syndrome Acute Middle Aged medicine.disease Immunohistochemistry eye diseases Ophthalmology medicine.anatomical_structure chemistry Immunology DNA Viral Female sense organs Choroid business |
| Zdroj: | Archives of ophthalmology (Chicago, Ill. : 1960). 110(8) |
| ISSN: | 0003-9950 |
| Popis: | • We describe the clinicopathologic and virologic findings in the right, blind eye of an immunocompetent 61-year-old woman. The eye was enucleated 32 months after the clinical onset of a bilateral acute retinal necrosis syndrome. Histopathologic study showed a diffuse, full-thickness, necrotizing retinitis with replacement of sensory retinal structures by glial tissue, occlusive retinal arteritis, granulomatous choroiditis, and optic neuritis with ischemic optic atrophy. Varicella zoster virus could be identified as the causative agent by DNA in situ hybridization and by immunohistochemical stains in mononuclear cells with eosinophilic intracytoplasmic inclusions. Virus was detected only within the choroid and the choriocapillaris. We conclude that these histopathologic and virologic features are consistent with a "burned-out phase" of a varicella zoster virus—induced acute retinal necrosis syndrome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|