Long-term follow-up of a hospital-based, multi-intervention programme in type 2 diabetes mellitus: impact on cardiovascular events and death
| Autor: | Morten W. Fagerland, Anne Pernille Ofstad, Lars Gullestad, Kåre I. Birkeland, Elsa Orvik, Odd Erik Johansen, Geir R. Ulimoen |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Time Factors Long term follow up 030204 cardiovascular system & hematology Biochemistry Clinical Reports 03 medical and health sciences cardiovascular events 0302 clinical medicine multifactorial treatment cardiovascular disease Medisinske Fag: 700 [VDP] Intervention (counseling) Type 2 diabetes mellitus Confidence Intervals Medicine Albuminuria Humans glitazones Artikkel VDP::Medisinske Fag: 700 030212 general & internal medicine Life Style business.industry Biochemistry (medical) Follow up studies Type 2 Diabetes Mellitus Cell Biology General Medicine Hospital based mortality Confidence interval Hospitals Diabetes Mellitus Type 2 Cardiovascular Diseases Female medicine.symptom business Follow-Up Studies |
| Zdroj: | The Journal of International Medical Research |
| Popis: | Objective To report the long-term impact on cardiovascular (CV) outcomes and mortality of a 2-year hospital-based multi-interventional care programme as compared with general practitioner (GP)-provided standard care. Methods Patients with type 2 diabetes with ≥ 1 additional CV risk factor were randomized to 2 years of specialist-based, multi-intervention comprising lifestyle modification and specific pharmacological treatment, or GP-based standard care. After the 2-year intervention period, all participants returned to pre-study care, but were followed up for CV outcomes and mortality. The primary outcome was time to any first severe CV event or death. Results A total of 120 patients (31 women) were enrolled in the study. During the mean ± SD observational period of 8.7 ± 2.0 years, 27 patients (16 and 11 in the multi-intervention and standard care groups, respectively) experienced at least one primary outcome event, with a hazard ratio (HR) if allocated to the multi-intervention group of 1.73 (95% confidence interval (CI) 0.80, 3.75). The HR for total mortality was 1.82 (95% CI 0.66, 5.01). Conclusions Hospital-based multi-intervention in patients with type 2 diabetes mellitus improved long-term glycaemic control, but failed to reduce CV outcomes and deaths. Clinical trials.gov id: NCT00133718. |
| Databáze: | OpenAIRE |
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