Primary angle-closure glaucomas disturb regional spontaneous brain activity in the visual pathway: an fMRI study
| Autor: | Yong-gen Xu, Man Luo, Li Zhang, Wei Chen, Kai Zhu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Cerebellum Neuropsychiatric Disease and Treatment Brain activity and meditation Optic disk Nerve fiber layer Glaucoma 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Ophthalmology medicine Original Research medicine.diagnostic_test business.industry retinal nerve fiber layer medicine.disease functional magnetic resonance imaging Lobe Visual cortex medicine.anatomical_structure primary angle-closure glaucoma regional homogeneity Functional magnetic resonance imaging business 030217 neurology & neurosurgery |
| Zdroj: | Neuropsychiatric Disease and Treatment |
| ISSN: | 1178-2021 1176-6328 |
| Popis: | Wei Chen, Li Zhang, Yong-gen Xu, Kai Zhu, Man Luo Department of Ophthalmology, Shaoxing People’s Hospital, Shaoxing, Zhejiang, People’s Republic of China Objective: To explore the underlying regional brain activity deficits in the visual cortex in patients with primary angle-closure glaucoma (PACG) relative to normal controls (NCs) using regional homogeneity (ReHo) method, and its relationship with behavioral performances. Patients: Twenty PACG patients (10 females, 10 males; mean age ± standard deviation [SD]: 54.42±9.46 years) and 20 age-, and sex status-matched NCs (10 females, 10 males; mean age± SD: 53.75±9.16 years) were included in this study. Measurements and results: Compared with NCs, patients with PACG showed significant atrophic peripapillary retinal nerve fiber layer (pRNFL) and neuroretinal rim area, increased optic disk cup-to-disc ratio (CDR) and optic disk volume (P |
| Databáze: | OpenAIRE |
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