Lateral Inhibition in the Human Visual System in Patients with Glaucoma and Healthy Subjects: A Case-Control Study
| Autor: | Marieke S A Janssens, Francisco G. Junoy Montolio, Wilma Meems, Nomdo M. Jansonius, Lucas Stam |
|---|---|
| Přispěvatelé: | Perceptual and Cognitive Neuroscience (PCN), Epidemiology |
| Rok vydání: | 2016 |
| Předmět: |
Retinal Ganglion Cells
Male Visual acuity Eye Diseases Light Visual Acuity Social Sciences Glaucoma lcsh:Medicine Inhibitions 0302 clinical medicine Animal Cells Lateral inhibition Medicine and Health Sciences Psychology Medicine Contrast (vision) ADAPTATION ABNORMALITIES lcsh:Science RETINA media_common Neurons Multidisciplinary Physics Electromagnetic Radiation Middle Aged Visual field medicine.anatomical_structure PARVOCELLULAR PATHWAYS Physical Sciences Visual Perception Sensory Perception Female Cellular Types Anatomy medicine.symptom OPEN-ANGLE GLAUCOMA SENSITIVITY Research Article medicine.medical_specialty Ganglion Cells Visible Light Ocular Anatomy media_common.quotation_subject Summation Retinal ganglion Contrast Sensitivity 03 medical and health sciences SDG 3 - Good Health and Well-being Ocular System Ophthalmology Psychophysics Humans Aged Behavior Retina DBA/2J MOUSE business.industry lcsh:R Biology and Life Sciences Afferent Neurons Cell Biology medicine.disease Luminance VISION Case-Control Studies 030221 ophthalmology & optometry Eyes lcsh:Q Visual Fields business Head 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE, 11(3):e0151006. PUBLIC LIBRARY SCIENCE PLoS ONE, Vol 11, Iss 3, p e0151006 (2016) PLoS ONE PLoS One (print), 11(3):e0151006. Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | In glaucoma, the density of retinal ganglion cells is reduced. It is largely unknown how this influences retinal information processing. An increase in spatial summation and a decrease in contrast gain control and contrast adaptation have been reported. A decrease in lateral inhibition might also arise. This could result in a larger than expected response to some stimuli, which could mask ganglion cell loss on functional testing (structure-function discrepancy). The aim of this study was to compare lateral inhibition between glaucoma patients and healthy subjects; we used a case-control design. Cases (n = 18) were selected to have advanced visual field loss in combination with a normal visual acuity. Controls (n = 50) were not allowed to have symptoms or signs of any eye disease. Lateral inhibition was measured psychophysically on a computer screen, with (1) a modified illusory movement experiment and (2) a contrast sensitivity (CS) test. Illusory movement was quantified by nulling it with a real movement; measure of lateral inhibition was the amount of illusory movement. CS was measured at 1 and 4 cycles per degree (cpd); measure of lateral inhibition was the difference between log CS at 4 and 1 cpd. Both measures were compared between cases and controls; analyses were adjusted for age and gender. There was no difference between cases and controls for these two measures of lateral inhibition (p = 0.58 for illusory movement; p = 0.20 for CS). The movement threshold was higher in cases than in controls (p = 0.008) and log CS was lower, at both 1 (-0.20; p = 0.008) and 4 (-0.28; p = 0.001) cpd. Our results indicate that spatially antagonisticmechanisms are not specifically affected in glaucoma, at least not in the intact center of a severely damaged visual field. This suggests that the structure-function discrepancy in glaucoma is not related to a decrease in lateral inhibition. |
| Databáze: | OpenAIRE |
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