The increased intrathecal expression of the monocyte-attracting chemokines CCL7 and CXCL12 in tick-borne encephalitis
| Autor: | Justyna Dunaj, Agnieszka Siemieniako, Sambor Grygorczuk, Anna Moniuszko-Malinowska, Piotr Czupryna, Renata Świerzbińska, Sławomir Pancewicz |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Central Nervous System Male 0301 basic medicine Adolescent Monocytes 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cerebrospinal fluid Monocytosis Meningoencephalitis Virology medicine Humans Chemokine CCL7 Aged Retrospective Studies Aged 80 and over Chemokine CCL20 business.industry Chemotaxis Macrophages Monocyte Tick-borne encephalitis Aseptic meningitis Middle Aged medicine.disease Chemokine CXCL12 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation Neurology Blood-Brain Barrier Case-Control Studies Immunology Female Neurology (clinical) business Meningitis Encephalitis Tick-Borne 030217 neurology & neurosurgery Encephalitis |
| Zdroj: | Journal of NeuroVirology. |
| ISSN: | 1538-2443 1355-0284 |
| DOI: | 10.1007/s13365-021-00975-z |
| Popis: | Tick-borne encephalitis (TBE) is a relatively severe and clinically variable central nervous system (CNS) disease with a significant contribution of a secondary immunopathology. Monocytes/macrophages play an important role in the CNS inflammation, but their pathogenetic role and migration mechanisms in flavivirus encephalitis in humans are not well known. We have retrospectively analyzed blood and cerebrospinal fluid (CSF) monocyte counts in 240 patients with TBE presenting as meningitis (n = 110), meningoencephalitis (n = 114), or meningoencephalomyelitis (n = 16), searching for associations with other laboratory parameters, clinical presentation, and severity. We have measured concentrations of selected monocytes-attracting chemokines (CCL7, CXCL12, CCL20) in serum and CSF of the prospectively recruited patients with TBE (n = 15), with non-TBE aseptic meningitis (n = 6) and in non-infected controls (n = 8). The data were analyzed with non-parametric tests, p |
| Databáze: | OpenAIRE |
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