Recombinant erythropoietin improves exercise capacity in anemic hemodialysis patients
| Autor: | John W. Adamson, Joseph W. Eschbach, H. Thomas Robertson, Diana D. Cardenas, N. Rebecca Haley, Mark R. Guthrie |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Anemia medicine.medical_treatment Isometric exercise Hematocrit Renal Dialysis Internal medicine Heart rate medicine Humans Erythropoietin Exercise Aged medicine.diagnostic_test business.industry VO2 max Middle Aged medicine.disease Recombinant Proteins Surgery Nephrology Cardiology Exercise Test Kidney Failure Chronic Female Hemodialysis business Respiratory minute volume medicine.drug |
| Zdroj: | American journal of kidney diseases : the official journal of the National Kidney Foundation. 15(4) |
| ISSN: | 0272-6386 |
| Popis: | The objective of this study was to quantitate the improvement in exercise capacity produced in anemic chronic hemodialysis (HD) patients after correction of their anemia with recombinant human erythropoietin (rHuEPO). The maximal exercise capacity and quadriceps strength of 19 anemic HD patients was tested before and after correction of the anemia with rHuEPO. A progressive work exercise protocol (PWET) on a cycle ergometer was used to compare measurements of maximal oxygen uptake (VO2max), maximal heart rate, and subjective assessment of fatigue during the test. Measurements of quadriceps strength were performed before the cycle ergometer studies. At baseline, all patients had reduced VO2max (15.3 +/- 5.4 mL/kg/min) and maximal exercise heart rates (138.5 +/- 23.9 beats/min). rHuEPO increased the mean hematocrit from 21.2% to 35%, and this was associated with a 17% increase (P less than 0.0005) in the VO2max. At any specified work load, rHuEPO treatment decreased heart rate, minute ventilation, and the subjective perception of fatigue. Both isometric and isokinetic measurements of quadriceps strength were improved following administration of rHuEPO. The maximal exercise heart rate was decreased in comparison to the baseline measurements (P less than 0.04), suggesting that in contrast to normal subjects, HD patients stop exercise before oxygen transport limitations are reached. In this unselected group of chronic HD patients, rHuEPO produced clinically significant improvements in both aerobic exercise capacity and isometric and isokinetic quadriceps strength. The improvement in aerobic capacity was substantially less than would have been expected from the correction of a comparable degree of anemia in non-HD patients. None of the 19 treated patients attained the exercise performance level predicted for a sedentary normal subject. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|