Exocarpic Acid Inhibits Mycolic Acid Biosynthesis inMycobacterium tuberculosis
| Autor: | Chris M. Ireland, Mohammad Sondossi, Michael Koch, Tim S. Bugni, Louis R. Barrows |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.drug_class
Antitubercular Agents Pharmaceutical Science Exocarpos latifolius Microbial Sensitivity Tests Biology Antimycobacterial Analytical Chemistry Diynes chemistry.chemical_compound Santalaceae Biosynthesis Amide Drug Discovery medicine Mode of action Pharmacology Fatty acid metabolism Organic Chemistry Mycobacterium tuberculosis biology.organism_classification Mycolic Acids Complementary and alternative medicine chemistry Mechanism of action Biochemistry Fatty Acids Unsaturated Molecular Medicine medicine.symptom Bacteria |
| Zdroj: | Planta Medica. 76:1678-1682 |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | Exocarpic acid (13 E-octadecene-9,11-diynoic acid) from Exocarpos latifolius R.Br. (Santalaceae) was previously shown to have specific antimycobacterial activity. Microarray data suggested inhibition of fatty acid metabolism as a potential mode of action. Experiments designed to elucidate the mechanism of action showed that exocarpic acid was effective at inhibition of mycolic acid biosynthesis and did not act by dissipating the proton gradient in treated M. tuberculosis. Amide derivatives of exocarpic acid displayed similar properties to exocarpic acid, while other polyacetylenic fatty acids varied in their effects on mycolic acid biosynthesis. |
| Databáze: | OpenAIRE |
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