Society of Toxicologic Pathology Position Paper on Best Practices on Recovery Studies
| Autor: | Charles W. Dean, Chuck Mahrt, Rick Perry, George L. Foley, Georgia Farris, Brian Short, Jean-Guy Bienvenu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Best practice Guidelines as Topic Cell Biology Toxicology Biopharmaceutics Pathology and Forensic Medicine Active participation Toxicology studies Research Design Toxicity Tests medicine Animals Position paper Risk assessment business Molecular Biology Anatomic pathologist |
| Zdroj: | Toxicologic Pathology. 41:1159-1169 |
| ISSN: | 1533-1601 0192-6233 |
| DOI: | 10.1177/0192623313481513 |
| Popis: | This article reviews the regulatory guidelines that provide for the inclusion of recovery groups in toxicology studies, presents the challenges in the design and interpretation of nonclinical recovery studies, and summarizes the best practices for the role of an anatomic pathologist regarding toxicology studies with recovery groups. Evaluating the potential recovery of histopathologic findings induced by a biopharmaceutical requires the active participation of one or more anatomic pathologists. Their expertise is critical in risk assessment regarding the potential for recovery as well as providing scientific guidance in the design and evaluation of studies with recovery groups. |
| Databáze: | OpenAIRE |
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