Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals
| Autor: | Robin M. Murray, Tuhina Lloyd, Gillian A. Doody, Abraham Reichenberg, Zefiro Mellacqua, Peter B. Jones, Ken D. Orr, Jolanta Zanelli, Craig Morgan, Gerard Hutchinson, Glynn Harrison, Paola Dazzan, Raymond C.K. Chan, Paul Fearon, J Eyeson, Kevin Morgan |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Adolescent Population Neuropsychological Tests Audiology Executive Function Young Adult medicine Humans Young adult Psychiatry education Biological Psychiatry Neurologic Examination Analysis of Variance education.field_of_study Working memory Cognition Middle Aged medicine.disease Executive functions Motor coordination Psychiatry and Mental health Psychotic Disorders Schizophrenia Regression Analysis Female Nervous System Diseases Cognition Disorders Psychology Psychomotor Performance |
| Zdroj: | Schizophrenia Research. 142:159-164 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2012.09.016 |
| Popis: | The minor neurological and cognitive deficits consistently reported in psychoses may reflect the same underlying brain dysfunction. Still, even in healthy individuals minor neurological abnormalities are associated with worse cognitive function. Therefore, establishing which neurological and cognitive deficits are specific to psychosis is essential to inform the pathophysiology of this disorder. We evaluated a large epidemiological sample of patients with first episode psychosis (n=242) and a population-based sample of healthy individuals (n=155), as part of the AESOP study. We examined neurological soft signs using the Neurological Evaluation Scale (Buchanan and Heinrichs, 1989), and generalized and specific cognitive deficits (memory; verbal abilities; attention, concentration and mental speed; executive functions and working memory; language; visual constructual/perceptual abilities). In patients, more neurological signs across all subscales were associated with worse general cognitive function, while in controls this was only present for sensory integration and sequencing signs. Furthermore, in patients, but not in healthy individuals, more sensory integrative signs were associated with deficits in specific cognitive domains, such as memory, verbal abilities, language, visual/perceptual, executive function (p ranging |
| Databáze: | OpenAIRE |
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