Study of the Antimicrobial Effect of an Ethanolic Extract of Propolis in Periodontal Disease

Autor: Esther Muñoz-Soto, Candela Reyes-Botella, Maria Victoria Olmedo-Gaya, Javier Díaz-Castro, Maria Jesús Lisbona-González, Jorge Moreno-Fernandez
Přispěvatelé: [Lisbona-González,MJ, Muñoz-Soto,E, Reyes-Botella,C, Olmedo-Gaya,MV] Department of Stomatology, School of Dentistry, University of Granada, Granada, Spain. [Diaz-Castro,J, Moreno-Fernandez,J] Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, Granada, Spain. [Diaz-Castro,J, Moreno-Fernandez,J] Institute of Nutrition and Food Technology 'José Mataix Verdú', University of Granada, Granada, Spain. [Diaz-Castro,J] nstituto de Investigación Biosanitaria (IBS), Granada, Spain., [Jesus Lisbona-Gonzalez, Maria] Univ Granada, Sch Dent, Dept Stomatol, Granada 18071, Spain, [Munoz-Soto, Esther] Univ Granada, Sch Dent, Dept Stomatol, Granada 18071, Spain, [Reyes-Botella, Candela] Univ Granada, Sch Dent, Dept Stomatol, Granada 18071, Spain, [Victoria Olmedo-Gaya, Maria] Univ Granada, Sch Dent, Dept Stomatol, Granada 18071, Spain, [Diaz-Castro, Javier] Univ Granada, Fac Pharm, Dept Physiol, Campus Univ Cartuja, Granada 18071, Spain, [Moreno-Fernandez, Jorge] Univ Granada, Fac Pharm, Dept Physiol, Campus Univ Cartuja, Granada 18071, Spain, [Diaz-Castro, Javier] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Granada 18071, Spain, [Moreno-Fernandez, Jorge] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Granada 18071, Spain, [Diaz-Castro, Javier] Inst Invest Biosanitaria IBS, Granada 18016, Spain, University of Granada, doctoral program in clinical medicine and public health
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Infección persistente
Technology
oral healing
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Microbiological Techniques::Bacteriological Techniques::Bacterial Load [Medical Subject Headings]
periodontal disease
Gastroenterology
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Gingivitis
Scaling and root planing
Própolis
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Dentistry::Periodontics::Dental Prophylaxis::Dental Scaling::Root Planing [Medical Subject Headings]
General Materials Science
Diseases::Stomatognathic Diseases::Mouth Diseases::Periodontal Diseases::Gingival Diseases::Gingivitis [Medical Subject Headings]
Biology (General)
Antiinfecciosos
Instrumentation
Adjuvant
Plaque
Fluid Flow and Transfer Processes
Organisms::Bacteria::Bacteroidetes::Bacteroidaceae::Prevotella::Prevotella intermedia [Medical Subject Headings]
biology
Physics
General Engineering
Prevotella intermedia
Treponema denticola
Periodontitis crónica
Engineering (General). Civil engineering (General)
Computer Science Applications
propolis
Chemistry
Antimicrobial effect
medicine.symptom
TA1-2040
Periodontal disease
medicine.medical_specialty
QH301-705.5
QC1-999
Bleeding on probing
Antimicrobial effectiveness
Chemicals and Drugs::Biological Factors::Antigens::Antigens
Bacterial::Tuberculin [Medical Subject Headings]
Propolis
Grupos control
Organisms::Bacteria::Bacteroidetes::Bacteroidaceae::Porphyromonas::Porphyromonas gingivalis [Medical Subject Headings]
Internal medicine
antimicrobial effect
medicine
Persons::Persons::Age Groups::Adult [Medical Subject Headings]
Porphyromonas gingivalis
QD1-999
Periodontitis
Capacity
business.industry
Process Chemistry and Technology
biology.organism_classification
medicine.disease
Chronic periodontitis
Oral healing
Enfermedades periodontales
business
Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Anaerobic Bacteria::Gram-Negative Anaerobic Straight
Curved
and Helical Rods::Spirochaetaceae::Treponema::Treponema denticola [Medical Subject Headings]
Diseases::Stomatognathic Diseases::Mouth Diseases::Periodontal Diseases::Periodontitis::Chronic Periodontitis [Medical Subject Headings]
Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Resins
Plant::Propolis [Medical Subject Headings]
Zdroj: Applied Sciences, Vol 11, Iss 7463, p 7463 (2021)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Applied Sciences
Volume 11
Issue 16
Popis: Periodontal disease encompasses gingivitis and periodontitis and is one of the most common chronic infections in the adult population. This study aimed to evaluate the influence of Spanish propolis extract (EEP) on the effect of the clinical and microbiological parameters as an adjuvant to scaling and root planning in patients undergoing supportive periodontal therapy (SPT). Forty chronic periodontitis patients were randomly assigned into two groups for the treatment. In the control group (n = 20), the sites were treated by scaling and root planing followed by gingival irrigation with physiological saline and in the test group (n = 20), the sites were treated by scaling and root planing followed by subgingival placement of EEP. At baseline (BL), bleeding on probing positive (BOP+) sites with probing pocket (PPD) ≥ 4 mm were defined as study sites. Plaque index, PPD, BOP, clinical attachment level (CAL), and subgingival plaque were evaluated at BL and 1 month later. The results showed a significant clinical improvement (p <
0.05) in the PPD, CAL and BOP+ comparing them with BL and one month after the periodontal treatment and a significant reduction (p <
0.05) for Tannerella forsythensis, Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola in both groups. In addition, the improvement of clinical parameters was observed with subgingival use of EEP and also statistically significant differences between groups were observed (p <
0.05) such as reductions of BOP+ % and reduced counts of T. forsythensis and P. gingivalis, considered as the “key pathogens” for the periodontal diseases. Our results suggest prophylactic and therapeutic potential for EEP against periodontal diseases, improving clinical parameters, reducing gingival bleeding and decreasing bacterial counts of T. forsythensis and P. gingivalis. The subgingival use of EEP represents a promising modality as an adjuvant in periodontal therapy to avoid microbial resistance and other adverse effects.
Databáze: OpenAIRE
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