Mechanisms of Peripheral Immune Tolerance: Conversion of the Immune to the Unresponsive Phenotype
| Autor: | Patrick J. Brennan, Sandra J. Saouaf, Yuan Shen, Mark I. Greene |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Clonal Anergy
Antigen Presentation Clonal anergy Immunology Antigen presentation Peripheral tolerance Receptors Interleukin-2 chemical and pharmacologic phenomena Biology Acquired immune system T-Lymphocytes Regulatory Immune tolerance Mice Phenotype T-Lymphocyte Subsets Immune Tolerance Animals Humans Cytotoxic T cell IL-2 receptor Antigen-presenting cell |
| Zdroj: | Immunologic Research. 28:193-200 |
| ISSN: | 0257-277X |
| DOI: | 10.1385/ir:28:3:193 |
| Popis: | Our studies on the immune response to foreign antigens are reviewed as they relate to the mechanisms of peripheral immune tolerance. The activation of suppressor T cells by distinct modes of antigen presentation is discussed. Through the use of mice expressing transgenic T-cell receptors specific for foreign antigens, we have concluded that the separable mechanisms of anergy and active suppression by CD25+ T cells work in concert to produce peripheral tolerance. In T-cell receptor Vbeta8.1 transgenic mice rendered tolerant of Mls-1a, the absence of the cell surface marker 6C10 defines the anergic population of CD4+ T cells, while 6C10+ CD4+ T cells are actively suppressed by CD25+ T cells. Through discussion of these observations, we have developed a historical perspective on recent advances in the understanding of mechanisms of peripheral tolerance. |
| Databáze: | OpenAIRE |
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