Determination of volatile residual solvents in pharmaceutical products by headspace liquid-phase microextraction gas chromatography-flame ionization detector
| Autor: | Jin-Peng Yuan, Jun-Bo Shi, Xia Wang, Jianhua Liu, Ru-Song Zhao, Chuan-Ge Cheng, Ting Jiang |
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| Rok vydání: | 2006 |
| Předmět: |
Flame Ionization
Detection limit Chromatography Gas Chromatography Volatilisation Chemistry Microchemistry Analytical chemistry Reproducibility of Results Residual Biochemistry Microanalysis Analytical Chemistry law.invention Column chromatography Pharmaceutical Preparations law Solvents By-product Flame ionization detector Gas chromatography Volatilization Drug Contamination |
| Zdroj: | Analytical and Bioanalytical Chemistry. 385:1082-1086 |
| ISSN: | 1618-2650 1618-2642 |
| Popis: | This paper demonstrates headspace liquid-phase microextraction (HS-LPME) as used for the determination of volatile residual solvents in pharmaceutical products. This method is based on headspace liquid-phase microextraction capillary column gas chromatography. Under optimum conditions, the linerary of the method ranged from 1 to 1,000 mg l(-1). The limits of detection are 0.2-6.0 [corrected] mg l(-1) and relative standard deviations (RSD) for most of the volatile solvents were below 10%. This novel method is applied to the analysis of volatile residual solvents in pharmaceutical products with satisfactory results. |
| Databáze: | OpenAIRE |
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