Retrospective validation of 11–13 weeks’ gestation ultrasound characteristics as predictive tools for twin-twin transfusion syndrome and selective intrauterine growth restriction in monochorionic diamniotic twin pregnancies
| Autor: | Yu-Ping Liao, Yin-Di Zhu, Jin-Yan Bian, Mei-Fang Pan, Ting Hu, You-Guo Chen, Xin-Xian Gu, Ming-Yue Wang |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Predictive marker Receiver operating characteristic Obstetrics business.industry Area under the curve Intrauterine growth restriction General Medicine Twin-to-twin transfusion syndrome medicine.disease Confidence interval medicine Gestation Original Article business Ductus venosus |
| Zdroj: | Ann Transl Med |
| ISSN: | 2305-5847 2305-5839 |
| Popis: | BACKGROUND: Twin to twin transfusion syndrome (TTTS) is a serious syndrome that can affect twin pregnancies involving a single placenta, impacts some of twin gestations with monochorionic diamniotic (MCDA) placentas. We validated the ultrasound characteristics of 11–13 weeks’ gestation to predict TTTS and selective intrauterine growth restriction (sIUGR) in MCDA pregnancies. METHODS: We retrospectively included all of the MCDA twin pregnancies with ultrasound characteristics, including the crown-rump length (CRL), ductus venosus pulsatility index for veins (DV PIV), and nuchal translucency (NT) thickness, at 11–13 weeks’ gestation, followed by mean difference and discordance comparison. Receiver operating characteristic (ROC) curves were constructed for the comparison of values of these predictive markers for identification of MCDA pregnancies with high-risk of adverse outcomes. RESULTS: A total of 98 MCDA pregnancies were included in this study. Among the 98, 34 (34.7%) developed sIUGR, whereas 10 (10.2%) expressed TTTS. Significant differences in NT discordance were found among the normal, sIUGR, and TTTS groups; moreover, a significant difference was found between pregnancies with normal outcomes and sIUGR (P |
| Databáze: | OpenAIRE |
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