Tenascin-C Expression in Papulosquamous Disorders Other than Psoriasis in Pediatric Patients: An Epiphenomenon?
| Autor: | F. Sule Afsar, Gülden Diniz, Safiye Aktaş |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Keratinocytes
Male Pathology medicine.medical_specialty Adolescent Skin Diseases Papulosquamous Dermatology Extracellular matrix Dermis Psoriasis Biopsy Humans Medicine Child medicine.diagnostic_test biology business.industry Tenascin C Tenascin medicine.disease Immunohistochemistry Epithelium Extracellular Matrix medicine.anatomical_structure Child Preschool Skin biopsy biology.protein Female Surgery business |
| Zdroj: | Journal of Cutaneous Medicine and Surgery. 15:1-7 |
| ISSN: | 1615-7109 1203-4754 |
| Popis: | Background: Tenascin-C is a large extracellular matrix protein that is expressed in the basal membrane zone during embryonic development, tissue repair, and oncogenesis. In vitro studies suggest that proliferating epithelium induces the production of tenascin-C by mesenchymal cells. Objective: Our goal was to compare the expression of tenascin-C in psoriasis with other papulosquamous disorders of the skin in pediatric patients. Methods: The study was conducted on skin biopsy samples of 37 patients with psoriasis or other papulosquamous disorders. Of the 37 skin biopsy samples, 17 (45.9%) were diagnosed as psoriasis and 20 (54.1%) were diagnosed as other papulosquamous disorders histopathologically, and the expression of tenascin-C was evaluated immunohistochemically. Results: Tenascin-C expression was seen in the dermis of lesional tissues or epidermal keratinocytes in 1 (5.8%) of the 17 biopsy samples diagnosed as psoriasis and 15 (75.0%) of the 20 biopsy samples diagnosed as other papulosquamous disorders ( p = .001). Conclusion: Tenascin-C expression was not found to be a staining characteristic of psoriasis lesions. But the significant staining intensity of the tenascin-C expression in other papulosquamous disorders suggests that tenascin-C expression might be an epiphenomenon in the papulosquamous disorders other than psoriasis immunohistochemically. Antécédents: La ténascine-C est une grande protéine de la matrice extracellulaire qui est exprimée dans la membrane basale durant le développement embryonnaire, le processus de réparation des tissus, et l'oncogenèse. Les études in vitro suggèrent que la prolifération épithéliale cause la production de la ténascine-C par les cellules mésenchymateuses. |
| Databáze: | OpenAIRE |
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