Synthesis, characterization and antimicrobial activity of Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands against bacteria and yeasts of clinical importance
| Autor: | Karina Marjorie Silva Herrera, Adriana Cristina Soares, Rafael César Russo Chagas, Lorena Sales Ferreira, Luis Fernando Soares, Juliano de Paula Souza, Jéssica Tauany Andrade, Alysson V. Braga, Jaqueline Maria Siqueira Ferreira |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
complexes
Multidisciplinary antimicrobial activity biology Ligand Science Thiazoline Broth microdilution chemistry.chemical_element Antimicrobial biology.organism_classification 1 2-bis-bis (2-thiazolin-2-isulfanyl) ethane Sulfur chemistry.chemical_compound Minimum inhibitory concentration chemistry hidrotris (2-mercaptothiazolyl) borate Derivative (chemistry) Bacteria Nuclear chemistry |
| Zdroj: | Anais da Academia Brasileira de Ciências v.91 n.4 2019 Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências (ABC) instacron:ABC Anais da Academia Brasileira de Ciências, Vol 91, Iss 4 (2019) Anais da Academia Brasileira de Ciências, Volume: 91, Issue: 4, Article number: e20181077, Published: 28 NOV 2019 |
| Popis: | Four novel Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands were synthesized and characterized using elemental, physiochemical, and spectroscopy analytical methods. The results showed the formation of ligands coordinated by sulfur atoms of the C = S bond to the L1 ligand and by the sulfur atom of the C-S bond and/or nitrogen of the intra C-ring bond of the L2 ligand. The activity of the complexes against Gram-negative, Gram-positive bacteria and yeasts of clinical importance was evaluated by broth microdilution method. The best result was obtained to L2-Ni compound against E. cloacae (Minimal Inhibitory Concentration (MIC) = 62.5 µg/mL). Additionally, the compounds showed anti-Candida activity (MIC values ranging from 250 to 500 µg/mL), except the L1-Cr that was not active against any tested microorganism. |
| Databáze: | OpenAIRE |
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