Immunocytological test to detect adult carriers of (--SEA/) deletional α-thalassaemia

Autor:	Barry Eng, John S. Waye, Wozhan Tang, Hong-yuan Luo, David H.K. Chui
Rok vydání:	1993
Předmět:	Adult Pathology medicine.medical_specialty Genotype business.industry Genetic Carrier Screening General Medicine Southeast asian Polymerase Chain Reaction Molecular biology Gene Frequency alpha-Thalassemia Humans Medicine Prospective Studies Positive test business Allele frequency Asia Southeastern
Zdroj:	The Lancet. 342:1145-1147
ISSN:	0140-6736
Popis:	The gene frequency for (SEA/) deletional α-thalassaemia is high in Southeast Asian populations. We report a simple immunocytological test that is higly sensitive and specific for the detection of adult carriers of the (SEA/) deletion. We prospectively studied 206 consecutive adult blood samples. All 41 with the (SEA/) deletion had a positive test; all but 1 of the 165 non-carriers were negative. This test, whose major requirement is a fluorescence microscope, should be useful to identify couples at risk of conceiving fetuses with homozygous α-thalassaemia. Lancet 1993; 342: 1145–47
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c65652fd2e07ce45ae7cff3268327f https://doi.org/10.1016/0140-6736(93)92125-d Zobrazit plný text záznamu Plný text ve formátu HTML
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