Autor: |
Barry Eng, John S. Waye, Wozhan Tang, Hong-yuan Luo, David H.K. Chui |
Rok vydání: |
1993 |
Předmět: |
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Zdroj: |
The Lancet. 342:1145-1147 |
ISSN: |
0140-6736 |
Popis: |
The gene frequency for (SEA/) deletional α-thalassaemia is high in Southeast Asian populations. We report a simple immunocytological test that is higly sensitive and specific for the detection of adult carriers of the (SEA/) deletion. We prospectively studied 206 consecutive adult blood samples. All 41 with the (SEA/) deletion had a positive test; all but 1 of the 165 non-carriers were negative. This test, whose major requirement is a fluorescence microscope, should be useful to identify couples at risk of conceiving fetuses with homozygous α-thalassaemia. Lancet 1993; 342: 1145–47 |
Databáze: |
OpenAIRE |
Externí odkaz: |
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