A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal transduction
| Autor: | Rudi J. Planta, Erno Vreugdenhil, Julian F. Burke, Cornelis P. Tensen, E. R. Van Kesteren, Kingsley J. A. Cox, H. van Heerikhuizen |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Signal peptide
Molecular Sequence Data Receptors Cell Surface Biology GTP-Binding Proteins Animals Humans 5-HT5A receptor Amino Acid Sequence Receptor Glucagon-like peptide 1 receptor Lymnaea Repetitive Sequences Nucleic Acid G protein-coupled receptor Multidisciplinary Base Sequence Sequence Homology Amino Acid DNA Alpha-2B adrenergic receptor Lipoproteins LDL Receptors LDL Biochemistry LDL receptor Signal transduction Signal Transduction Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 91:4816-4820 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.91.11.4816 |
| Popis: | We have isolated and analyzed a cDNA from the central nervous system of the mollusc Lymnaea stagnalis encoding a putative receptor, which might be a natural hybrid between two different classes of receptor proteins. Preceded by a signal peptide, two types of repeated sequences are present in the N-terminal part of the protein. The first repeat displays a high sequence similarity to the extracellular binding domains of the low density lipoprotein receptor, which binds and internalizes cholesterol-containing apolipoproteins. The second repeat and the C-terminal part of the Lymnaea receptor are very similar to regions of a specific class of guanine nucleotide-binding protein-coupled receptors, the mammalian glycoprotein hormone receptors. The mRNA encoding the receptor is predominantly expressed in a small number of neurons within the central nervous system and to a lesser extent in the heart. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|