Lung Stereotactic Body Radiation Therapy (SBRT) dose gradient and PTV volume: a retrospective multi-center analysis
| Autor: | David J. Hoopes, Ryan P. Manger, Irena Dragojević, Jeremy D.P. Hoisak, D Hoffman |
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| Rok vydání: | 2019 |
| Předmět: |
Organs at Risk
Percentile Lung Neoplasms medicine.medical_treatment Radiotherapy Planning Retrospective 0302 clinical medicine Computer-Assisted Intensity-Modulated Gradient index Radiation treatment planning Lung Cancer SBRT Gradient measure Lung Cancer Radiotherapy Dosage lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognosis Tumor Burden medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Lung cancer lcsh:Medical physics. Medical radiology. Nuclear medicine Stereotactic body radiation therapy lcsh:R895-920 Oncology and Carcinogenesis Radiosurgery lcsh:RC254-282 03 medical and health sciences medicine Humans Radiology Nuclear Medicine and imaging Oncology & Carcinogenesis Retrospective Studies Radiotherapy business.industry Research Radiotherapy Planning Computer-Assisted Dose gradient medicine.disease Radiation therapy Radiotherapy Intensity-Modulated Nuclear medicine business Volume (compression) |
| Zdroj: | Radiation oncology (London, England), vol 14, iss 1 Radiation Oncology, Vol 14, Iss 1, Pp 1-7 (2019) Radiation Oncology (London, England) |
| Popis: | Background The treatment of lung lesions with stereotactic body radiation therapy calls for highly conformal dose, which is evaluated by a number of metrics. Lung stereotactic body radiation therapy clinical trials constrain a plans gradient index. The purpose of this work is to describe the dependence of clinically achievable dose gradient on planning target volume. Methods Three hundred seventy-four lung stereotactic body radiation therapy treatment plans were retrospectively reviewed and selected for this study. The relationship between R50% and planning target volume size was observed and compared against the RTOG 0915 and 0813 constraints noting minor and major deviations. Then a least squares regression was used to determine the coefficients for a power functional form of the dependence of gradient measure (GM) on planning target volume size. Results Of the 317 peripheral lung SBRT plans, 142 exhibited no deviation, 135 exhibited a minor deviation, and 40 exhibited a major deviation according to the RTOG 0915 dosimetric. conformality and dose fall-off constraints. A plot of gradient measure versus planning target volume size for peripheral lesions, excluding RTOG 0915 major deviations, is fit with an power function of GM = 0.564 V0.215. Conclusions Using the PTV size and GM relationship we have characterized, treatment plans with PTV |
| Databáze: | OpenAIRE |
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