Effect of amphotericin B on the lipids of five different strains of Cryptococcus neoformans
| Autor: | Sarah Piancastelli Franzot, Júnia Soares Hamdan |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Veterinary (miscellaneous)
Microbial Sensitivity Tests Applied Microbiology and Biotechnology Microbiology chemistry.chemical_compound Minimum inhibitory concentration Membrane Lipids Postoperative Complications Amphotericin B Ergosterol polycyclic compounds medicine Humans Cerebrospinal Fluid Cryptococcus neoformans biology AIDS-Related Opportunistic Infections Fungi imperfecti Cryptococcosis biology.organism_classification Kidney Transplantation Yeast Sterol Sterols Biochemistry chemistry lipids (amino acids peptides and proteins) Agronomy and Crop Science Quantitative analysis (chemistry) medicine.drug |
| Zdroj: | Mycopathologia. 128(2) |
| ISSN: | 0301-486X |
| Popis: | Cells of five strains ofCryptococcus neoformans were obtained for partial analysis of lipid composition. Quantitative analysis of lipids and sterols were completed, as well as qualitative analysis of sterols by thin-layer chromatography and by the ultraviolet spectra. Such determinations were made on cells cultured in the absence and presence of amphotericin B at sub-MIC (minimal inhibitory concentration) levels. Marked alterations of the lipid and sterol contents were observed in the amphotericin B — treated cells. Moreover, ergosterol disappeared in these antibiotic-exposed cells. It is concluded that amphotericin B altered the lipid profiles, especially sterols ofC. neoformans. |
| Databáze: | OpenAIRE |
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