MicroProteins: Expanding functions and novel modes of regulation
| Autor: | Kaushal Kumar Bhati, Ulla Dolde, Stephan Wenkel |
|---|---|
| Přispěvatelé: | Université Catholique de Louvain = Catholic University of Louvain (UCL), Laboratoire de Recherche en Sciences Végétales (LRSV), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Copenhagen = Københavns Universitet (KU), This work was supported by a Charge de Researcher fellowship (no. 19516174) from the Fonds de la Recherche Scientifique, Belgium (to K.K.B.) and a Deutsche Forschungsgemeinschaft postdoc fellowship (to U.D.). The laboratory of Stephan Wenkel is funded by grants from the Independent Research Fund Denmark (0136-00015B and 0135-00014B) and the Novo Nordisk Foundation (NNF18OC0034226, NNF19OC005658, and NNF20OC0061440). |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0303 health sciences Arabidopsis MEDLINE Proteins Plant Science Computational biology Biology 01 natural sciences 03 medical and health sciences Gene Expression Regulation Plant Mutation [SDV.BV]Life Sciences [q-bio]/Vegetal Biology Protein Interaction Domains and Motifs Molecular Biology 030304 developmental biology 010606 plant biology & botany |
| Zdroj: | Molecular Plant Molecular Plant, Cell Press/Oxford UP, 2021, 14 (5), pp.705-707. ⟨10.1016/j.molp.2021.01.006⟩ |
| ISSN: | 1674-2052 1752-9867 |
| DOI: | 10.1016/j.molp.2021.01.006⟩ |
| Popis: | International audience; MicroProteins are small, 5–15-kDa single-domain proteins that are evolutionarily related to multi-domain proteins with sequence homology (Eguen et al., 2015). The single domain of microProteins is often a protein–protein interaction (PPI) domain, through which they can interact with their multi-domain protein targets (Figure 1). The first experimental insight that microProteins exist and how they act came from the identification of the regulatory feedback mechanism of class III homeodomain-leucine zipper (HD-ZIPIII) transcription factors by LITTLE ZIPPER (ZPR) microProteins (Wenkel et al., 2007; Kim et al., 2008). In Arabidopsis, the LITTLE ZIPPER microProtein family consists of four members (ZPR1-4) containing only a leucine zipper domain. The HD-ZIPIII transcription factor REVOLUTA directly transcriptionally upregulates multiple ZPR genes. ZPR proteins physically interact with their HD-ZIPIII targets and suppress their DNA binding ability. Thus, ZPRs establish a direct negative feedback module that controls the activity of the shoot apical meristem. |
| Databáze: | OpenAIRE |
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