Comparing different NTCP models that predict the incidence of radiation pneumonitis
| Autor: | José Belderbos, Mary K. Martel, Randall K. Ten Haken, Yvette Seppenwoolde, James A. Hayman, Cees Schilstra, Joos V. Lebesque, Katrien De Jaeger, G.T. Henning, Liesbeth J. Boersma |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Cancer Research
Dose-volume histogram medicine.medical_treatment CELL LUNG-CANCER Normal tissue PARALLEL ARCHITECTURE NTCP NORMAL TISSUE THERAPY Median toxic dose medicine Radiology Nuclear Medicine and imaging TOLERANCE Lung cancer Radiation Pneumonitis radiotherapy DAMAGE Radiation business.industry COMPLICATION PROBABILITY Incidence (epidemiology) DOSE-VOLUME HISTOGRAM medicine.disease IRRADIATION Radiation therapy lung cancer Oncology WHOLE Probability distribution radiation pneumonitis Nuclear medicine business |
| Zdroj: | International Journal of Radiation Oncology Biology Physics, 55(3), 724-735. ELSEVIER SCIENCE INC |
| ISSN: | 1879-355X 0360-3016 |
| Popis: | Purpose: To compare different normal tissue complication probability (NTCP) models to predict the incidence of radiation pneumonitis on the basis of the dose distribution in the lung.Methods and Materials: The data from 382 breast cancer, malignant lymphoma, and inoperable non-small-cell lung cancer patients from two centers were studied. Radiation pneumonitis was scored using the Southwestern Oncology Group criteria. Dose-volume histograms of the lungs were calculated from the dose distributions that were corrected for dose per fraction effects. The dose-volume histogram of each patient was reduced to a single parameter using different local dose-effect relationships. Examples of single parameters were the mean lung dose (MLD) and the volume of lung receiving more than a threshold dose (V-Dth). The parameters for the different NTCP models were fit to patient data using a maximum likelihood analysis.Results: The best fit resulted in a linear local dose-effect relationship, with the MLD as the resulting single parameter. The relationship between the MLD and NTCP could be described with a median toxic dose (TD50) of 30.8 Gy and a steepness parameter m of 0.37. The best fit for the relationship between the V-Dth and the NTCP was obtained with a D-th of 13 Gy. The MLD model was found to be significantly better than the VIth model (p 35%. For arbitrary dose distributions, an estimate of the uncertainty in the NTCP could be determined using the probability distribution of the parameter values of the Lyman-Kutcher-Burman model.Conclusion: The maximum likelihood method revealed that the underlying local dose-effect relation for radiation pneumonitis was linear (the MLD model), rather than a step function (the V-Dth model). Thus, for the studied patient population, the MLD was the most accurate predictor for the incidence of radiation pneumonitis. (C) 2003 Elsevier Science Inc. |
| Databáze: | OpenAIRE |
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